p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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Studies of the VGF promoter have identified a number of consensus sites in a minimal 110 bp promoter spanning -180 to -70 upstream of the transcriptional start site (D'Arcangelo et al, 1996; Possenti et al, 1992; Mandolesi et al, 2002). These sites, which include an E-box, a CCAAT site, a CRE element and a G(S)G site, are required for NGF-responsive transcription in neuronal cells (Possenti et al, 1992; D'Arcangelo et al, 1996; Mandolesi et al, 2002). The E box and CCAAT elements are bound by TCF12 (also known as HEB) and ASCL1 (also known as MASH1) to weakly stimulate trancriptional activity (Di Rocco et al, 1997; Mandolesi et al, 2002). The CRE is bound by phosphorylated CREB and by members of the ATF family . CRE binding is facilitated through protein-protein interactions with an unidentified CCAAT-binding factor (Di Rocco et al, 1997; D'Arcangelo et al, 1996; Mandolesi et al, 2002). The CREB:ASCL1 complex also includes the histone acetyltransferase p300 (Mandolesi et al, 2002; Adams et al, 2017).
Literature References
PubMed ID Title Journal Year
9032251 Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene

Di Rocco, G, Pennuto, M, Illi, B, Nasi, S, Trani, E, Mandolesi, G, Sirinian, MI, Levi, A, Filocamo, G, Jucker, R, Possenti, R, Canu, N, Rinaldi, AM

Mol. Cell. Biol. 1997
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S

PLoS ONE 2017
11755530 NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction

Mandolesi, G, Gargano, S, Molfetta, R, Pennuto, M, Illi, B, Nasi, S, Levi, A, Jucker, R, Mosca, L, Soucek, L

FEBS Lett. 2002
1570299 Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene

Di Rocco, G, Nasi, S, Levi, A, Possenti, R

Proc. Natl. Acad. Sci. U.S.A. 1992
8756618 Activation of codependent transcription factors is required for transcriptional induction of the vgf gene by nerve growth factor and Ras

D'Arcangelo, G, Salton, SR, Halegoua, S, Habas, R, Wang, S

Mol. Cell. Biol. 1996
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