Reactome | HMGCR [endoplasmic reticulum membrane]

HMGCR [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9621345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMDH_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04035 HMGCR

Gene Names

HMGCR

Chain

chain:1-888

Reference Genes

BioGPS Gene:3156 HMGCR

COSMIC (genes):HMGCR HMGCR

CTD Gene:3156 HMGCR

dbSNP Gene:3156 HMGCR

ENSEMBL:ENSG00000113161 HMGCR

ENSEMBL_homo_sapiens_GENE:ENSG00000113161.17 HMGCR

HGNC:5006 HMGCR

KEGG Gene (Homo sapiens):3156 HMGCR

Monarch:3156 HMGCR

NCBI Gene:3156 HMGCR

OMIM:142910 HMGCR

UCSC:P04035 HMGCR

Reference Transcript

Other Identifiers

11727374_s_at

11727375_a_at

11727376_a_at

16986249

202539_PM_s_at

202539_s_at

202540_PM_s_at

202540_s_at

2815966

2815968

2815969

2815970

2815971

2815973

2815977

2815978

2815979

2815980

2815981

2815982

2815983

2815987

2815988

2815990

2815992

2815994

2815995

2815996

2815997

2816000

2816001

2816002

2816003

2816004

2816005

2816006

2816007

2816008

2816009

2816012

2816013

3156

39328_at

43868_at

8106280

A_14_P126678

A_14_P201160

A_23_P30495

GE61694

GO:0003824

GO:0004420

GO:0005515

GO:0005777

GO:0005778

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0006695

GO:0008202

GO:0008203

GO:0008299

GO:0008542

GO:0015936

GO:0016020

GO:0016126

GO:0016491

GO:0016616

GO:0023052

GO:0030163

GO:0030695

GO:0042177

GO:0043226

GO:0050661

GO:0050709

GO:0050877

GO:0055086

GO:0060291

GO:0070372

GO:0070402

GO:0098772

GO:0120225

GO:1900222

GO:1901135

HMNXSV003007418

Hs.11899.0.S2_3p_a_at

M11058_at

PH_hs_0001121

TC05000363.hg

TC05002453.hg

TC05002454.hg

g4557642_3p_a_at

p26865

Participates

as an output of

HMGCR gene expression (Homo sapiens)

Cross References

RefSeq

XP_011541659.1, NP_001124468.1, XP_011541660.1, NP_000850.1

ZINC - World Drugs

HMDH_HUMAN

Guide to Pharmacology - Targets

639

OpenTargets

ENSG00000113161

ZINC - FDA approved

HMDH_HUMAN

ZINC - Substances

HMDH_HUMAN

ZINC - Biogenic

HMDH_HUMAN

ZINC target

P04035

PRO

P04035

PDB

3CD5, 3CCZ, 1HWJ, 3CDB, 1DQ9, 2Q6B, 2Q1L, 3CD7, 1HW9, 2Q6C, 1HWL, 3BGL, 1DQA, 3CDA, 1DQ8, 3CCT, 1HWI, 1HW8, 1HWK, 3CCW, 3CD0, 2R4F

ZINC - Metabolites

HMDH_HUMAN

GeneCards

P04035

HPA

ENSG00000113161-HMGCR

Ensembl

ENSP00000287936, ENSP00000426745, ENST00000681410, ENST00000680940, ENSP00000505805, ENST00000681271, ENSG00000113161, ENST00000287936, ENSP00000340816, ENSP00000506232, ENSP00000505561, ENST00000343975, ENST00000511206

Pharos - Targets

P04035

ZINC - Predictions - Purchasable

HMDH_HUMAN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.463	3