Reactome | HSP90AA1 [lysosomal lumen]

HSP90AA1 [lysosomal lumen]

Stable Identifier

R-HSA-9622850

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07900 HSP90AA1

Gene Names

HSP90AA1, HSP90A, HSPC1, HSPCA

Chain

initiator methionine:, chain:2-732

Reference Genes

BioGPS Gene:3320 HSP90AA1

COSMIC (genes):HSP90AA1 HSP90AA1

CTD Gene:3320 HSP90AA1

dbSNP Gene:3320 HSP90AA1

ENSEMBL:ENSG00000080824 HSP90AA1

ENSEMBL_homo_sapiens_GENE:ENSG00000080824.19 HSP90AA1

HGNC:5253 HSP90AA1

KEGG Gene (Homo sapiens):3320 HSP90AA1

Monarch:3320 HSP90AA1

NCBI Gene:3320 HSP90AA1

OMIM:140571 HSP90AA1

UCSC:P07900 HSP90AA1

Reference Transcript

Other Identifiers

11732996_at

11749934_s_at

11758308_s_at

16796829

210211_PM_s_at

210211_s_at

211968_PM_s_at

211968_s_at

211969_PM_at

211969_at

214328_PM_s_at

214328_s_at

2362304

2545387

2751645

2755868

2755880

2793561

2793563

2793567

32316_s_at

3320

3367313

3367314

3367315

3367316

3367317

3367319

3367320

3367322

3367324

3367325

3367327

3367328

3367329

3580178

3580180

3580181

3580182

3580184

3580185

3580187

3580188

3580190

3580192

3580194

3580196

3580197

3580198

3580200

3580203

3580204

3580207

3580208

3580210

3580211

3580219

3580230

7981335

A_23_P162866

A_23_P162874

A_33_P3665777

GE59722

GO:0000166

GO:0001764

GO:0001934

GO:0002134

GO:0002135

GO:0002218

GO:0002230

GO:0002376

GO:0003009

GO:0003012

GO:0003013

GO:0003723

GO:0003729

GO:0003824

GO:0005515

GO:0005524

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0005929

GO:0006457

GO:0006839

GO:0006886

GO:0006913

GO:0006914

GO:0006986

GO:0007004

GO:0007005

GO:0008092

GO:0009408

GO:0009409

GO:0009410

GO:0009651

GO:0009986

GO:0010592

GO:0010659

GO:0012501

GO:0016020

GO:0016323

GO:0016324

GO:0016787

GO:0016887

GO:0017098

GO:0019903

GO:0023026

GO:0030154

GO:0030163

GO:0030235

GO:0030312

GO:0030911

GO:0031012

GO:0031396

GO:0031410

GO:0031526

GO:0031625

GO:0032200

GO:0032273

GO:0032564

GO:0032728

GO:0032880

GO:0032991

GO:0034605

GO:0034774

GO:0036126

GO:0036211

GO:0042026

GO:0042220

GO:0042307

GO:0042470

GO:0042802

GO:0042803

GO:0042826

GO:0042981

GO:0043025

GO:0043202

GO:0043209

GO:0043226

GO:0043254

GO:0043335

GO:0043627

GO:0044183

GO:0044294

GO:0044295

GO:0044325

GO:0045040

GO:0045429

GO:0045732

GO:0045793

GO:0046677

GO:0048156

GO:0048471

GO:0048856

GO:0048870

GO:0050821

GO:0050877

GO:0051020

GO:0051022

GO:0051082

GO:0051131

GO:0051973

GO:0060452

GO:0061024

GO:0061684

GO:0062023

GO:0065003

GO:0070062

GO:0070182

GO:0071682

GO:0097110

GO:0097226

GO:0097524

GO:0097718

GO:0098542

GO:0098586

GO:0098772

GO:0099072

GO:0140657

GO:0140662

GO:1902949

GO:1904813

GO:1905323

GO:1990782

HMNXSV003006689

Hs.289088.4.A1_3p_at

Hs.289088.4.A2_3p_a_at

ILMN_1691097

ILMN_2373515

PH_hs_0033549

TC14001526.hg

TC14002169.hg

X15183_at

g3287488_3p_a_at

Participates

as a member of

HSP90AA1, HSP90AB1 [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

HSP90AA1 [secretory granule lumen]

HSP90AA1 [ficolin-1-rich granule lumen]

HSP90AA1 [plasma membrane]

HSP90AA1 [endocytic vesicle lumen]

HSP90AA1 [extracellular region]

HSP90AA1 [nucleoplasm]

HSP90AA1 [cytosol]

Cross References

RefSeq

NP_005339.3, NP_001017963.2

Guide to Pharmacology - Targets

2905

OpenTargets

ENSG00000080824

ZINC - Substances

HS90A_HUMAN

ZINC target

P07900

ZINC - Biogenic

HS90A_HUMAN

PRO

P07900

PDB

2CCS, 3RLP, 2BUG, 6EL5, 4AWP, 4O0B, 2WI1, 2YEG, 4XIR, 3VHC, 2YI0, 2WI2, 4L90, 4CWQ, 4BQG, 8W8K, 1UYG, 3D0B, 6GR5, 7S98, 2BZ5, 4R3M, 4EFT, 5XQE, 6GPF, 6FDP, 4O04, 5J64, 2YE5, 2XDX, 4O05, 5J9X, 2YK9, 3R4N, 7UR3, 5LQ9, 3HHU, 7KW7, 2XJJ, 6GPT, 3K98, 7S9G, 3OWD, 4LWE, 1UYD, 3HZ1, 2BT0, 5OCI, 4L94, 2YE9, 6TN5, 2CCT, 5LS1, 6ELP, 4L8Z, 2YEJ, 6GPH, 3INX, 4CWP, 1OSF, 2YKE, 1UY7, 3EKO, 5J27, 5LRL, 2YI7, 6GPW, 4YKT, 5FNC, 5J8M, 5XQD, 5NYI, 3B26, 5XRD, 3T0H, 6LR9, 2K5B, 5M4H, 3FT5, 3R4M, 2YE6, 4FCP, 4LWI, 3R91, 6FCJ, 2XDK, 7LSZ, 4LWF, 4CGU, 4NH8, 1UYE, 6KSQ, 2XDL, 4YKY, 3B24, 2CCU, 6U98, 5LNY, 3T2S, 5J80, 3HZ5, 6GR4, 1UYH, 5VYY, 2XHR, 3B27, 2YEB, 5OD7, 4U93, 3Q6N, 1UYI, 8FFV, 5XRE, 6N8X, 1UY6, 4FCR, 4CWR, 1BYQ, 7S90, 3K99, 3FT8, 3BM9, 6GPR, 6GQR, 4B7P, 3OW6, 3EKR, 2UWD, 6GP8, 3T0Z, 8B7I, 5LO1, 4NH7, 5GGZ, 4YKX, 2YEF, 4EGK, 1UYF, 2FWY, 5LRZ, 4YKU, 5FND, 8AGL, 2H55, 5T21, 6ELN, 4AWQ, 6HHR, 4FCQ, 5NYH, 6CYG, 2XJG, 4JQL, 2YKI, 8X2R, 2YEC, 7S8Z, 2YJW, 4W7T, 6U9B, 1YER, 7S9H, 5M4E, 8KI4, 6GQS, 4EFU, 4XIT, 1YC1, 6EYB, 6U9A, 2WI7, 1YES, 3TUH, 5LR7, 7S9F, 4CWO, 4L93, 4XIP, 3R4O, 2YEH, 2XK2, 2XJX, 5ODX, 3OWB, 2YKB, 3HEK, 1UY9, 2FWZ, 3Q6M, 6LTK, 2YI5, 4O07, 3RLR, 5XR5, 7S99, 6B9A, 5FNF, 1UY8, 4YKW, 3QDD, 2YI6, 6GQ6, 6ELO, 2QFO, 7RY1, 2C2L, 2YE3, 8AGI, 2QG0, 2YE4, 2YKJ, 4EEH, 6OLX, 2JJC, 4YKQ, 6GP4, 5XRB, 2YEE, 3HYY, 2YE8, 5J2V, 5J82, 4CGV, 3WHA, 3VHD, 5LO5, 6U99, 4CWN, 6EY9, 5XR9, 6GPP, 5J6L, 7LT0, 6CEO, 2WI3, 3R92, 4L91, 5LR1, 2VCI, 2YE2, 2YEI, 3RLQ, 6CYH, 2WI4, 6GR3, 6LTI, 2VCJ, 4CWS, 6B99, 4BQJ, 4LWG, 5J2X, 3B28, 7DMC, 2YE7, 6EYA, 5ZR3, 2BSM, 6F1N, 5CF0, 4HY6, 7L7J, 2YKC, 4EGI, 7L7I, 1YC3, 7KRJ, 3WQ9, 6TN4, 6EY8, 5LO0, 3HYZ, 2YEA, 4CGW, 8AGJ, 7RY0, 2YK2, 3T1K, 7S95, 2WI5, 6GQU, 8FFW, 5J20, 2WI6, 2QG2, 4CGQ, 5LO6, 5J6M, 5J86, 4CWF, 3VHA, 4LWH, 6LSZ, 5J6N, 3RKZ, 1UYC, 4CWT, 3R4P, 4EGH, 3QTF, 2QF6, 5J8U, 1YET, 5LNZ, 3INW, 2BYH, 3T10, 4XIQ, 4AIF, 3O0I, 4AWO, 2BYI, 6GPO, 2XDS, 2XAB, 1YC4, 3B25, 8W4V, 4O09, 7RXZ, 6EI5, 4YKR, 2XDU, 2YJX, 3K97, 6GPY, 2XHT, 3MNR, 3BMY, 6GR1, 1UYK, 6LT8, 7S8Y, 4YKZ, 7S9I, 2YED, 1UYL, 8B7J, 2XHX

ZINC - Investigational

HS90A_HUMAN

GeneCards

P07900

HPA

ENSG00000080824-HSP90AA1

Ensembl

ENSG00000080824, ENSP00000216281, ENST00000334701, ENST00000216281, ENSP00000335153

Pharos - Targets

P07900

ZINC - Predictions - Purchasable

HS90A_HUMAN

HMDB Protein

HMDBP02801

Interactors (111)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.899	17
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.873	13
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.857	9
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.856	6
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.851	6
UniProt:Q9H6T3 RPAP3			0.85	7
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.832	7
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.831	9
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.8	8
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.8	9
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.788	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.788	15
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.784	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.778	7
UniProt:P04150 NR3C1	3	SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106) NR3C1 [cytosol] (R-HSA-5618118) NR3C1 [nucleoplasm] (R-HSA-879837)	0.775	8
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.744	5
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.744	6
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.744	6
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.744	15
UniProt:P08107 HSP71			0.723	4
UniProt:Q9UHD1 CHRD1			0.681	8
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.678	4
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.669	6
UniProt:Q9BXA6 TSSK6			0.669	4
UniProt:Q8IWD4 CC117			0.669	7
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.669	4
UniProt:Q96QS6 PSKH2			0.669	3
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.669	8
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.669	4
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.669	3
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.666	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	5
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.666	5
UniProt:O95433 AHSA1			0.659	6
UniProt:P11802 CDK4	3	CDK4 [cytosol] (R-HSA-68330) CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830)	0.643	4
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.635	3
UniProt:O43318-2 MAP3K7			0.623	5
UniProt:P35467	1	S100A1 [extracellular region] (R-RNO-6805991)	0.618	4
UniProt:Q8WVJ2 NUDC2			0.612	4
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.612	5
UniProt:Q9H0C5 BTBD1	1	BTBD1 [cytosol] (R-HSA-8851650)	0.61	4
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.589	2
UniProt:Q13127 REST	1	REST [nucleoplasm] (R-HSA-480506)	0.57	4
UniProt:P14616 INSRR			0.569	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	11
UniProt:Q7L3B6 CDC37L1	2	CDC37L1 [extracellular region] (R-HSA-8848918) CDC37L1 [platelet dense granule lumen] (R-HSA-8848903)	0.564	3
UniProt:Q96Q40 CDK15			0.564	3
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.564	2
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.564	2
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.564	3
UniProt:Q9Y243 AKT3	6	p-T305-AKT3 [cytosol] (R-HSA-3009370) AKT3 [cytosol] (R-HSA-2976007) AKT3 [plasma membrane] (R-HSA-2976006) p-S472-AKT3 [plasma membrane] (R-HSA-3009363) p-T305,S472-AKT3 [cytosol] (R-HSA-3009367) p-T305,S472-AKT3 [nucleoplasm] (R-HSA-3009365)	0.564	4
UniProt:P00540 MOS			0.564	2
UniProt:Q16671 AMHR2	1	AMHR2 [plasma membrane] (R-HSA-8858258)	0.564	3
UniProt:Q8IWX7 UN45B			0.564	3
UniProt:Q9NR20 DYRK4			0.564	2
UniProt:Q9UHH9 IP6K2	1	IP6K2 [nucleoplasm] (R-HSA-1015687)	0.558	2
UniProt:Q14194 CRMP1	4	p-Y-CRMP1 [cytosol] (R-HSA-399784) CRMP1 [cytosol] (R-HSA-398120) p-T509,T514,S518,S522-CRMP1 [cytosol] (R-HSA-399777) p-S522-CRMP1 [cytosol] (R-HSA-399779)	0.556	3
UniProt:Q92993-2 KAT5			0.556	3
UniProt:Q15438 CYTH1	2	CYTH1 [cytosol] (R-HSA-8847826) CYTH1 [Golgi membrane] (R-HSA-8847825)	0.556	3
UniProt:Q8WUY3 PRUN2			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q6QEF8-4 CORO6			0.556	3
UniProt:Q9H6R7-2 Q9H6R72			0.556	3
UniProt:Q9BV29 CCD32			0.556	3
UniProt:Q96LI6-3 Q96LI63			0.556	3
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.556	3
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.544	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.536	2
UniProt:Q9H1R3 MYLK2			0.527	8
UniProt:P68371 TUBB4B	8	TUBB4B [cytosol] (R-HSA-191702) TUBB4B [azurophil granule lumen] (R-HSA-6799347) TUBB4B [extracellular region] (R-HSA-6806178) TUBB4B [axonemal microtubule] (R-HSA-5610441) Polyglutamyl-TUBB4B [cytosol] (R-HSA-8867427) Polyglycyl-TUBB4B [cytosol] (R-HSA-8867452) TUBB4B unfolded [cytosol] (R-HSA-392779) TUBB4B folding intermediate [cytosol] (R-HSA-392788)	0.527	2
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A(1-450) [cytosol] (R-HSA-8955577) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433)	0.527	3
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.527	3
UniProt:Q3B7T1 EDRF1			0.527	6
UniProt:Q8N5M4 TTC9C			0.527	5
UniProt:O75676 RPS6KA4	1	RPS6KA4 [cytosol] (R-HSA-772527)	0.527	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.527	3
UniProt:Q9HBY8 SGK2	1	SGK2 [cytosol] (R-HSA-2682364)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.527	3
UniProt:Q9H9G7 AGO3	1	EIF2C3 [cytosol] (R-HSA-210615)	0.527	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.527	3
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.527	2
UniProt:Q6J9G0 STYK1			0.527	2
UniProt:Q92918 M4K1			0.527	2
UniProt:Q15785 TOM34			0.527	4
UniProt:Q8NFD2 ANKK1			0.527	2
UniProt:Q9UQ88 CDK11A	1	CDK11A [cytosol] (R-HSA-380457)	0.527	4
UniProt:P49761 CLK3			0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.527	3
UniProt:O94966 USP19	1	USP19 [cytosol] (R-HSA-6781794)	0.527	7
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.527	3
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.527	4
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.527	2
UniProt:Q13163 MAP2K5	1	MAP2K5 [cytosol] (R-HSA-198722)	0.527	3
UniProt:P34932 HSPA4	2	HSPA4 [cytosol] (R-HSA-5251946) HSPA4 [nucleoplasm] (R-HSA-5251998)	0.527	2
UniProt:O95801 TTC4			0.527	4
UniProt:Q8TDR2 STK35			0.527	3
UniProt:Q14004 CDK13	3	CDK13 [nucleoplasm] (R-HSA-6797014) CDK13 [ficolin-1-rich granule lumen] (R-HSA-6801374) CDK13 [extracellular region] (R-HSA-6806442)	0.527	3
UniProt:Q8WTQ7 GRK7	1	GRK7 [photoreceptor disc membrane] (R-HSA-6787797)	0.527	2
UniProt:Q8N165 PDK1L			0.527	2
UniProt:Q86YV6 MYLK4			0.527	2
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.527	3
UniProt:Q9H3Y6 SRMS	1	SRMS [cytosol] (R-HSA-3902520)	0.527	3
UniProt:Q08881 ITK	3	p-Y180,Y512-ITK [cytosol] (R-HSA-2685616) p-Y512-ITK [cytosol] (R-HSA-422519) ITK [cytosol] (R-HSA-202319)	0.527	2
UniProt:P26882 PPID			0.525	4
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.524	2
UniProt:Q9D1P4 CHRD1			0.508	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	13

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