Reactome | AGRP [nucleoplasm]

AGRP [nucleoplasm]

Stable Identifier

R-HSA-9623016

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Agouti-related protein, AGRP_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P04183 TK1

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - FOXO-mediated transcription (Homo sapiens)
      - FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
        
        AGRP gene expression is stimulated by FOXO1 (Homo sapiens)
        
        AGRP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00253 AGRP

Gene Names

AGRP, AGRT, ART

Chain

signal peptide:1-20, propeptide:21-82, chain:83-132

Reference Genes

BioGPS Gene:181 AGRP

COSMIC (genes):AGRP AGRP

CTD Gene:181 AGRP

dbSNP Gene:181 AGRP

ENSEMBL:ENSG00000159723 AGRP

HGNC:330 AGRP

KEGG:hsa:181 AGRP

Monarch:181 AGRP

NCBI Gene:181 AGRP

OMIM:602311 AGRP

UCSC:O00253 AGRP

Reference Transcript

RefSeq:NM_001138.1 AGRP

Other Identifiers

11715289_s_at

11730571_at

16827381

181

207193_PM_at

207193_at

35068_at

3695727

3695728

3695729

3695731

3695732

3695733

8002051

A_33_P3279470

GO:0005102

GO:0005184

GO:0005576

GO:0005615

GO:0005794

GO:0005796

GO:0007218

GO:0007623

GO:0007631

GO:0008343

GO:0009755

GO:0022414

GO:0032868

GO:0042755

GO:0043025

GO:0043226

GO:0048018

GO:0048571

GO:0060135

GO:0060259

GO:0070996

GO:0098772

GO:2000253

HMNXSV003006487

ILMN_1714253

ILMN_1770336

PH_hs_0005805

TC16001191.hg

g4501994_3p_at

Participates

as an output of

AGRP gene expression is stimulated by FOXO1 (Homo sapiens)

Cross References

ENSEMBL

ENSP00000290953, ENST00000290953

OpenTargets

ENSG00000159723

HPA

ENSG00000159723-AGRP

PRO

O00253

Pharos - Targets

O00253

PDB

1HYK, 1MR0

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NR09 BIRC6	2	BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713451) BIRC6(1-958)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713450)	0.527	2
UniProt:Q9H672 ASB7	1	ASB7 [cytosol] (R-HSA-975425)	0.527	2
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.527	2
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.527	2
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.527	2
UniProt:Q5JS37 NHLRC3	2	NHLRC3 [extracellular region] (R-HSA-6806222) NHLRC3 [azurophil granule lumen] (R-HSA-6799213)	0.527	2

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