Based on studies in mice, FOXO1 represses transcription of the POMC gene, encoding Pro-opiomelanocortin, in hypothalamic anorexigenic neurons. FOXO1-mediated repression of the POMC gene involves the recruitment of histone deacetylases and the NcoR repressor complex to the POMC gene promoter. Leptin inhibits binding of FOXO1 and promotes binding of STAT3 to the POMC gene promoter, thus stimulating POMC gene transcription. One of the cleavage products of Pro-opiomelanocortin is melanocyte-stimulating hormone alpha, which suppresses food intake (Kitamura et al. 2006, Kim et al. 2006).