Delayed Early (DE) Gene Expression

Stable Identifier
R-HSA-9623096
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Following peak expression of major immediate early (MIE) regulatory proteins, the second class of early genes, delayed early (DE), become transcriptionally active independent of the host cell type. Although some DE gene products are produced in abundance from the start, most of the proteins and assorted miRNAs accumulate gradually. The DE period of viral replication continues until viral DNA synthesis initiates. DE genes are crucial for viral DNA synthesis and include several functions that become important later in infection for maturation and egress. Many DE genes have a substantial impact on replication when disrupted. DE gene products dispensable for replication in fibroblasts may contribute to modulation of the host cell and host animal response to infection. Several HCMV DE genes switch or add transcriptional start sites later in infection, which means that transcript levels represent the combined products of different kinetic classes of gene expression.

Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

  2013
Participants
Output
Participates
Event Information
Go Biological Process
This event is regulated
Disease
Name Identifier Synonyms
disease by infectious agent DOID:0050117 infectious disease
Reviewed
Created
Cite Us!