ESR1-dependent CCND1 expression

Stable Identifier
R-HSA-9623355
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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ESR1-dependent CCND1 expression
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Expression of CCND1, the gene encoding cyclin D1, is stimulated by treatment of cells with E2. Expression is dependent on ESR1-mediated signaling through the PKA and AKT pathways, and consistent with this, levels of phosphorylated CREB1 increase upon treatment with E2. The CCND1 promoter has a CRE element that is bound by phosphorylated CREB1 upon E2 treatment as assessed by electrophoretic mobility shift assay (Park et al, 2001; Felty et al, 2005).
Literature References
PubMed ID Title Journal Year
11243864 Reduction in cyclin D1/Cdk4/retinoblastoma protein signaling by CRE-decoy oligonucleotide

Park, YG, Park, S, Lim, SO, Lee, MS, Ryu, CK, Kim, I, Cho-Chung, YS

Biochem. Biophys. Res. Commun. 2001
15897899 Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling

Felty, Q, Singh, KP, Roy, D

Oncogene 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CCND1 gene:p-S133 CREB1 dimer [nucleoplasm] (Homo sapiens)
Active Unit
p-S133-CREB1 [nucleoplasm]
Authored
Rothfels, K  (2018-12-15)
Reviewed
Levin, ER  (2019-02-20)
Created
Rothfels, K  (2018-10-04)
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