BCL2 mRNA and protein levels increase in response to E2 stimulation in a PKA-dependent manner (Grimaldi et al, 2002; Yune et al, 2008). Levels of phosphorylated CREB1 also increase with estrogen stimulation, however direct binding of phosphorylated CREB to the BCL2 promoter has not been demonstrated. Estrogen-dependent BCL2 expression is also dependent on Sp1 (Dong et al, 1999; Yune et al, 2008; reviewed in Ladikou and Kassi, 2017).
Yune, TY, Park, HG, Oh, TH, Lee, JY
Dong, L, Stoner, M, Vyhlidal, C, Kladde, MP, Samudio, I, Wang, W, Safe, S, Harigai, M, Reed, JC, Wang, F
Diamond, B, Cleary, J, Moussai, D, Grimaldi, CM, Dagtas, AS
Kassi, E, Ladikou, EE
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