Reactome | AREG(101-187) [extracellular region]

AREG(101-187) [extracellular region]

Stable Identifier

R-HSA-9624190

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

fullName evidence="8"Amphiregulin, AREG_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
  - Signaling by EGFR in Cancer (Homo sapiens)
    - Signaling by Overexpressed Wild-Type EGFR in Cancer (Homo sapiens)
      - Inhibition of Signaling by Overexpressed EGFR (Homo sapiens)
        
        Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)
        
        EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:EGFR dimer [plasma membrane] (Homo sapiens)
        
        EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:EGFR dimer [plasma membrane] (Homo sapiens)
        
        EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EGF-like ligands [extracellular region] (Homo sapiens)
        
        AREG(101-187) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15514 AREG

Gene Names

AREG, AREGB, SDGF

Chain

signal peptide:1-19, propeptide:20-100, chain:101-187, propeptide:188-252

Reference Genes

BioGPS Gene:374 AREG

COSMIC (genes):AREG AREG

CTD Gene:374 AREG

dbSNP Gene:374 AREG

ENSEMBL:ENSG00000109321 AREG

ENSEMBL_homo_sapiens_GENE:ENSG00000109321.11 AREG

HGNC:651 AREG

KEGG Gene (Homo sapiens):374 AREG

Monarch:374 AREG

NCBI Gene:374 AREG

OMIM:104640 AREG

UCSC:P15514 AREG

Reference Transcript

RefSeq:NM_001657.3 AREG

Other Identifiers

11715306_s_at

16967853

16967863

205239_PM_at

205239_at

2731541

2731543

2731544

2731545

2731546

2731547

2731548

2731552

2731553

2731554

2731555

2731556

2731558

2731561

34898_at

374

8095736

8095744

A_14_P115708

A_23_P259071

A_33_P3419190

GE62938

GO:0005125

GO:0005154

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005783

GO:0005789

GO:0007173

GO:0007186

GO:0007267

GO:0008083

GO:0008284

GO:0009986

GO:0010838

GO:0012507

GO:0014009

GO:0014070

GO:0016020

GO:0022414

GO:0023052

GO:0030154

GO:0030297

GO:0030669

GO:0031175

GO:0031410

GO:0032355

GO:0033116

GO:0036211

GO:0038134

GO:0042327

GO:0042542

GO:0043226

GO:0043434

GO:0045668

GO:0048018

GO:0048856

GO:0050731

GO:0051384

GO:0051591

GO:0060598

GO:0060744

GO:0060749

GO:0060750

GO:0098772

HMNXSV003029092

M30703_s_at

PH_hs_0013934

PH_hs_0035731

TC04002952.hg

TC04002953.hg

g4502198_3p_at

Participates

as a member of

EGF-like ligands [extracellular region] (Homo sapiens)

Other forms of this molecule

AREG(101-187) [clathrin-coated endocytic vesicle membrane]

AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]

AREG precursor [ER to Golgi transport vesicle membrane]

AREG precursor [endoplasmic reticulum membrane]

Inferred To

areg [extracellular region] (Xenopus tropicalis)

Areg [extracellular region] (Mus musculus)

Areg [extracellular region] (Rattus norvegicus)

AREG(101-187) [extracellular region] (Danio rerio)

AREG [extracellular region] (Bos taurus)

AREG [extracellular region] (Canis familiaris)

AREG [extracellular region] (Gallus gallus)

AREG [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001648.1

OpenTargets

ENSG00000109321

ZINC - Substances

AREG_HUMAN

HPA

ENSG00000109321-AREG

GeneCards

P15514

Ensembl

ENST00000395748, ENSG00000109321, ENSP00000379097

ZINC target

P15514

PRO

P15514

Pharos - Targets

P15514

ZINC - Predictions - Purchasable

AREG_HUMAN

PDB

2RNL

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26447 S10A4			0.683	5
IntAct:EBI-10171679 386682			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P06921 VE2			0.488	2

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