AKT phosphorylation of the pro-apoptotic Forkhead transcription factor FOXO3 and other Foxo family members occurs downstream of E2 stimulation (Richards et al, 2002; reviewed in Levin, 2005). AKT-mediated phosphorylation promotes nuclear export, resulting in a decrease in expression of apoptosis-promoting FOXO3-target genes (Brunet et al, 1999; reviewed in Burgering, 2008).
Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC
Burgering, BM
Lo, YH, Falender, AE, Richards, JS, Sharma, SC
Levin, ER
protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
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