GCK gene expression is inhibited by FOXO1, SIN3A and HDACs

Stable Identifier
R-HSA-9625124
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GCK gene expression is inhibited by FOXO1, SIN3A and HDACs
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mice, FOXO1, together with SIN3A and histone deacetylases (HDACs), directly represses transcription of the GCK gene, encoding glucokinase. Insulin interferes with FOXO1-mediated repression of GCK expression, resulting in upregulation of GCK and stimulation of lipogenesis (Langlet et al. 2017).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
FOXO1:SIN3A:HDAC1.HDAC2 dimers:GCK gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1:SIN3A:HDAC1,HDAC2 dimers [nucleoplasm]
Inferred From
Gck gene expression is inhibited by Foxo1, Sin3a and Hdac (Mus musculus)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-19)
Cite Us!