Apoptosis is a controlled process of cell death, which must be tightly regulated to ensure that potentially dangerous cells are efficiently removed, while cells that are transiently stressed by environmental conditions can recover and survive (Bratton SB & Salvesen GS 2010). Defects in the regulation of apoptosis have been associated with the pathogenesis of disease states such as neurodegeneration and cancer (Favaloro B et al. 2012). The mitochondrial or intrinsic apoptotic pathway is regulated at multiple steps, including apoptosome formation and caspase‑9 activation.
Bratton, SB, Salvesen, GS
Shakeri, R, Kheirollahi, A, Davoodi, J
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