Protein hydroxylation

Stable Identifier
Homo sapiens
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This pathway groups reactions mediated by 2-OG (2-oxoglutarate)-dependent oxygenases that target proline, lysine, asparagine, arginine, aspartate, and histidine residues of diverse proteins, with effects that potentially modulate transcription and translation (Herr & Hausinger 2018; Markolovic et al. 2015; Stoehr et al. 2016; Zurlo et al. 2016).

The roles of members of this enzyme family in collagen assembly are annotated separately in pathway R-HSA-1650814, "Collagen biosynthesis and modifying enzymes".

Literature References
PubMed ID Title Journal Year
27095734 Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes

Murphy, E, Kloner, PH, Evangelista, AM, Lin, Y, Wang, G, Aponte, A, Boylston, J, Stoehr, A, Zhu, J, Yang, Y, Gucek, M, Patel, S, Liu, P

Cardiovasc. Res. 2016
29709390 Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases

Hausinger, RP, Herr, CQ

Trends Biochem. Sci. 2018
26152730 Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases

Markolovic, S, Schofield, CJ, Wilkins, SE

J. Biol. Chem. 2015
27663420 New Insights into Protein Hydroxylation and Its Important Role in Human Diseases

Zurlo, G, Takada, M, Zhang, Q, Wei, W, Guo, J

Biochim. Biophys. Acta 2016
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