Reactome | 5OHK15,276-U2AF2 [nucleoplasm]

5OHK15,276-U2AF2 [nucleoplasm]

Stable Identifier

R-HSA-9630011

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

5OHK15,276-U2AF 65 kDa subunit, 5OHK15,276-Splicing factor U2AF 65 kDa subunit, 5OHK15,276-U2 auxiliary factor 65 kDa subunit, 5OHK15,276-U2 snRNP auxiliary factor large subunit, 5OHK15,276-hU2AF(65)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P26368 U2AF2

Gene Names

U2AF2, U2AF65

Chain

initiator methionine:, chain:2-475

Reference Genes

COSMIC (genes):U2AF2 U2AF2

dbSNP Gene:11338 U2AF2

ENSEMBL:ENSG00000063244 U2AF2

Participates

as an output of

JMJD6 dimer hydroxylates lysine residues of U2AF2 (Homo sapiens)

Other forms of this molecule

U2AF2 [nucleoplasm]

Inferred To

U2af50 [nucleoplasm] (Drosophila melanogaster)

U2AF2 [nucleoplasm] (Bos taurus)

U2AF2 [nucleoplasm] (Canis familiaris)

U2AF2 [nucleoplasm] (Sus scrofa)

5OHK15,276-U2AF2 [nucleoplasm] (Gallus gallus)

5OHK15,276-U2AF2 [nucleoplasm] (Plasmodium falciparum)

u2af2 [nucleoplasm] (Dictyostelium discoideum)

u2af2 [nucleoplasm] (Xenopus tropicalis)

uaf-1 [nucleoplasm] (Caenorhabditis elegans)

MUD2 [nucleoplasm] (Saccharomyces cerevisiae)

prp2 [nucleoplasm] (Schizosaccharomyces pombe)

U2af2 [nucleoplasm] (Mus musculus)

U2af2 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

5-hydroxy-L-lysine at 15

Coordinate

PsiMod Name

(2S,5R)-5-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.

Name

5-hydroxy-L-lysine at 276

Coordinate

276

PsiMod Name

(2S,5R)-5-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.948	23
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.948	14
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.849	7
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.803	8
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.727	6
UniProt:Q8IWZ8 SUGP1	1	SUGP1 [nucleoplasm] (R-HSA-72043)	0.713	4
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.707	4
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.703	5
UniProt:P54253 ATX1			0.674	5
UniProt:Q9NVV9 THAP1			0.666	4
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.64	4
UniProt:Q99590 SCAFB			0.64	5
UniProt:Q8IX12 CCAR1	1	CCAR1 [nucleoplasm] (R-HSA-72048)	0.64	3
UniProt:P98175 RBM10	1	RBM10 [nucleoplasm] (R-HSA-9770262)	0.632	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.629	3
UniProt:Q8N684 CPSF7	2	CPSF7 [cytosol] (R-HSA-9715140) CPSF7 [nucleoplasm] (R-HSA-72012)	0.618	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.618	3
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.615	5
UniProt:Q9NWB6 ARGL1			0.583	4
UniProt:Q15287 RNPS1	2	RNPS1 [cytosol] (R-HSA-159256) RNPS1 [nucleoplasm] (R-HSA-156778)	0.564	4
UniProt:Q9UI36-2 DACH1			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P62995 TRA2B	2	TRA2B [cytosol] (R-HSA-9715137) TRA2B [nucleoplasm] (R-HSA-8850859)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.527	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.519	2
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.519	2
UniProt:Q96PU8 QKI	2	QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] (R-HSA-6802546) QKI(1-504)-RAF1(278-648) fusion [cytosol] (R-HSA-6802466)	0.519	2
UniProt:Q9BWF3 RBM4	1	RBM4 [cytosol] (R-HSA-8878898)	0.519	2
UniProt:Q7Z7F0 KHDC4			0.519	2
UniProt:Q86VM9 ZCH18			0.483	3
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.483	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:Q86XP3 DDX42	1	DDX42 [nucleoplasm] (R-HSA-8867894)	0.483	2
UniProt:O15042 U2SURP	1	U2SURP [nucleoplasm] (R-HSA-8865950)	0.483	4
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.483	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.483	3
UniProt:P46013 KI67			0.483	2
UniProt:Q9UKJ3 GPTC8			0.483	2
UniProt:Q9NYF8 BCLF1			0.483	3
UniProt:Q9NW64 RBM22	1	RBM22 [nucleoplasm] (R-HSA-5215975)	0.483	2
UniProt:P15941 MUC1	19	MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.471	2
UniProt:P82979 SARNP	1	SARNP [nucleoplasm] (R-HSA-8849146)	0.471	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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