Reactome | RPL8 [nucleoplasm]

RPL8 [nucleoplasm]

Stable Identifier

R-HSA-9630985

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

60S ribosomal protein L8, RL8_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9UHB9 SRP68

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External Reference Information

External Reference

UniProt:P62917 RPL8

Gene Names

RPL8

Chain

initiator methionine:, chain:2-257

Reference Genes

BioGPS Gene:6132 RPL8

COSMIC (genes):RPL8 RPL8

CTD Gene:6132 RPL8

dbSNP Gene:6132 RPL8

ENSEMBL:ENSG00000161016 RPL8

HGNC:10368 RPL8

KEGG:hsa:6132 RPL8

Monarch:6132 RPL8

NCBI Gene:6132 RPL8

OMIM:604177 RPL8

UCSC:P62917 RPL8

Reference Transcript

Other Identifiers

11744120_a_at

11753565_x_at

11756258_x_at

17082873

200936_PM_at

200936_at

31505_at

3159032

3159041

3159042

3159043

3159044

3159045

3159046

3159047

3159048

3159049

3159050

3159051

3159052

3159053

3159054

3159055

3159056

3159057

3159058

3159059

3159060

3159062

3928439

6132

8153903

A_23_P31654

GE60384

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0014069

GO:0015934

GO:0016020

GO:0019843

GO:0022625

GO:0022626

GO:0043226

GO:0045202

GO:0098794

GO:1990904

HMNXSV003000800

HMNXSV003004133

HMNXSV003042588

ILMN_1764721

ILMN_1811433

PH_hs_0010606

TC08001762.hg

Z28407_at

g4506662_3p_at

Participates

as an input of

RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Homo sapiens)

Other forms of this molecule

RPL8 [cytosol]

3OHH216-RPL8 [nucleoplasm]

Inferred To

RPL2A [nucleoplasm] (Saccharomyces cerevisiae)

rpl801 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of RPL8 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of RPL8 [nucleoplasm] (Schizosaccharomyces pombe)

RpL8 [nucleoplasm] (Drosophila melanogaster)

rpl802 [nucleoplasm] (Schizosaccharomyces pombe)

rpl803 [nucleoplasm] (Schizosaccharomyces pombe)

rpl-2 [nucleoplasm] (Caenorhabditis elegans)

Rpl8 [nucleoplasm] (Mus musculus)

Rpl8 [nucleoplasm] (Rattus norvegicus)

rpl8 [nucleoplasm] (Danio rerio)

rpl8 [nucleoplasm] (Dictyostelium discoideum)

rpl8 [nucleoplasm] (Xenopus tropicalis)

RPL2B [nucleoplasm] (Saccharomyces cerevisiae)

RPL8 [nucleoplasm] (Bos taurus)

RPL8 [nucleoplasm] (Canis familiaris)

RPL8 [nucleoplasm] (Gallus gallus)

RPL8 [nucleoplasm] (Plasmodium falciparum)

RPL8 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001304700.1, NP_150644.1, NP_001304711.1, NP_000964.1

OpenTargets

ENSG00000161016

ENSEMBL

ENSP00000433464, ENST00000262584, ENSP00000378378, ENSP00000262584, ENST00000528957, ENST00000394920

HPA

ENSG00000161016-RPL8

PRO

P62917

Pharos - Targets

P62917

GlyGen

P62917

PDB

6OLE, 6OLF, 4CCM, 7BHP, 8INF, 4V6X, 8INE, 6ZMI, 4UG0, 7XNX, 8IE3, 6OM7, 8FLC, 6Z6L, 8QFD, 6Z6M, 8INK, 8JDK, 8FLD, 8FLB, 8JDM, 6LSR, 7XNY, 4CCO, 6LQM, 6ZM7, 8FL9, 8IR3, 8IDY, 8FL6, 6IP6, 4Y3O, 6LU8, 8IPX, 5AJ0, 5T2C, 8FKZ, 6Y2L, 8IPD, 8FL2, 8FL4, 7OW7, 8FLA, 8JDL, 8Y0X, 4CCN, 8JDJ, 8A3D, 8OJ5, 8Y0W, 8FLF, 6OLZ, 8IFE, 5LKS, 7UN3, 6LSS, 8OJ8, 6OM0, 6OLI, 6Z6N, 8FLE, 8IFD, 6ZMO, 6Y6X, 6OLG, 8QOI, 6Y0G, 6IP8, 6XA1, 7F5S, 8FL7, 8IR1, 6IP5, 8IDT, 8OHD, 8IPY, 6QZP, 6W6L, 8OJ0, 8FL3, 6ZME, 6Y57

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	20
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.528	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	2
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:O43167 ZBT24			0.527	2
UniProt:Q8NDF8 PAPD5			0.527	3
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:Q96ME7 ZN512			0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:Q13823 NOG2			0.527	2
UniProt:Q6PK04 CC137			0.527	2
UniProt:Q15397 PUM3			0.527	3
UniProt:Q15050 RRS1			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:Q14684 RRP1B			0.527	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.527	2
UniProt:Q9GZR2 REXO4			0.527	2
UniProt:P51608 MECP2			0.527	3
UniProt:Q02543 RPL18A	1	RPL18A [cytosol] (R-HSA-72422)	0.527	2
UniProt:P42696 RBM34			0.527	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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