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PRMT1 [cytosol]
Stable Identifier
R-HSA-9632173
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HRMT1L2, Protein arginine N-methyltransferase 1, Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4, HMT2, IR1B4
Locations in the PathwayBrowser for interactor UniProt:Q96BD6 SPSB1
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
Nucleoprotein is methylated by PRMT1 (Homo sapiens)
PRMT1 [cytosol] (Homo sapiens)
PRMT1 binds type I PRMT inhibitors (Homo sapiens)
PRMT1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
PRMT1 methylates ESRs (Homo sapiens)
PRMT1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99873 PRMT1
Gene Names
PRMT1, HMT2, HRMT1L2, IR1B4
Chain
chain:1-371
Reference Genes
BioGPS Gene:3276 PRMT1
COSMIC (genes):PRMT1 PRMT1
CTD Gene:3276 PRMT1
dbSNP Gene:3276 PRMT1
ENSEMBL:ENSG00000126457 PRMT1
ENSEMBL_homo_sapiens_GENE:ENSG00000126457.22 PRMT1
HGNC:5187 PRMT1
KEGG Gene (Homo sapiens):3276 PRMT1
Monarch:3276 PRMT1
NCBI Gene:3276 PRMT1
OMIM:602950 PRMT1
UCSC:Q99873 PRMT1
Reference Transcript
RefSeq:XM_017026735.1 PRMT1
RefSeq:NM_198318.4 PRMT1
RefSeq:XM_017026734.1 PRMT1
RefSeq:NM_001207042.2 PRMT1
RefSeq:NM_001536.5 PRMT1
Other Identifiers
11715825_a_at
11760492_x_at
206445_PM_s_at
206445_s_at
3276
32825_at
3838813
3838814
3838815
3838817
3838820
3838821
3838822
3838824
3838825
3838827
3838828
3838831
3838832
3838834
3838838
3838839
8030437
A_21_P0000175
GE81037
GO:0001701
GO:0002376
GO:0003677
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006479
GO:0006807
GO:0007166
GO:0008168
GO:0008170
GO:0008276
GO:0008284
GO:0008327
GO:0008380
GO:0016274
GO:0016740
GO:0018216
GO:0019082
GO:0019899
GO:0023052
GO:0030154
GO:0030510
GO:0031175
GO:0032259
GO:0034709
GO:0035241
GO:0035242
GO:0036211
GO:0042054
GO:0042802
GO:0043170
GO:0043226
GO:0044020
GO:0044238
GO:0045648
GO:0045652
GO:0045653
GO:0045727
GO:0046329
GO:0046985
GO:0048273
GO:0048738
GO:0048856
GO:0051260
GO:0061431
GO:0065003
GO:0106080
GO:0140096
GO:1900745
GO:1904047
GO:1904263
HMNXSV003017987
HMNXSV003022154
ILMN_2347234
PH_hs_0028792
TC19002199.hg
TC19002646.hg
Y10807_s_at
g4504496_3p_s_at
Participates
as an input of
PRMT1 binds type I PRMT inhibitors (Homo sapiens)
as a component of
PRMT1:type I PRMT inhibitors [cytosol] (Homo sapiens)
Other forms of this molecule
PRMT1 [nucleoplasm]
Inferred To
PRMT1 [cytosol]
(Bos taurus)
PRMT1 [cytosol]
(Canis familiaris)
PRMT1 [cytosol]
(Mus musculus)
PRMT1 [cytosol]
(Rattus norvegicus)
PRMT1 [cytosol]
(Sus scrofa)
PRMT1 [cytosol]
(Xenopus tropicalis)
Art8 [cytosol]
(Drosophila melanogaster)
Art2 [cytosol]
(Drosophila melanogaster)
Dmel\CG32152 [cytosol]
(Drosophila melanogaster)
Art1 [cytosol]
(Drosophila melanogaster)
Art6 [cytosol]
(Drosophila melanogaster)
Art9 [cytosol]
(Drosophila melanogaster)
Homologues of PRMT1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001527.3
,
XP_016882223.1
,
NP_001193971.1
,
XP_016882224.1
,
NP_938074.2
ZINC - World Drugs
ANM1_HUMAN
Guide to Pharmacology - Targets
1252
OpenTargets
ENSG00000126457
ZINC - Substances
ANM1_HUMAN
ZINC target
Q99873
ZINC - Biogenic
ANM1_HUMAN
PRO
Q99873
PDB
6NT2
ZINC - Metabolites
ANM1_HUMAN
GeneCards
Q99873
HPA
ENSG00000126457-PRMT1
Ensembl
ENST00000391851
,
ENST00000610806
,
ENST00000454376
,
ENSP00000484505
,
ENSP00000375724
,
ENSG00000126457
,
ENSP00000406162
Pharos - Targets
Q99873
ZINC - Predictions - Purchasable
ANM1_HUMAN
HMDB Protein
HMDBP11614
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43390 HNRNPR
1
HNRNPR [nucleoplasm]
(R-HSA-71951)
0.742
5
UniProt:Q12906 ILF3
3
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [cytosol]
(R-HSA-450564)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.727
4
UniProt:Q99873 PRMT1
2
PRMT1 [cytosol]
(R-HSA-9632173)
PRMT1 [nucleoplasm]
(R-HSA-3215140)
0.721
4
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.657
5
UniProt:Q9NR22 ANM8
0.632
5
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.623
2
UniProt:P22736 NR4A1
2
p-S351-NR4A1 [nucleoplasm]
(R-HSA-199846)
NR4A1 [nucleoplasm]
(R-HSA-199831)
0.623
6
UniProt:P48552 NRIP1
2
monoSUMO1-K756,K1154-NRIP1 [nucleoplasm]
(R-HSA-4086057)
NRIP1 [nucleoplasm]
(R-HSA-4086031)
0.602
4
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.602
3
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.564
3
UniProt:Q9Y3Y2 CHTOP
1
CHTOP [nucleoplasm]
(R-HSA-8849147)
0.564
5
UniProt:Q9NR22-2 PRMT8
0.556
5
UniProt:Q15772 SPEG
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:P49761 CLK3
0.527
2
UniProt:P19784 CSNK2A2
2
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
CSNK2A2 [cytosol]
(R-HSA-201721)
0.527
2
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.527
2
UniProt:Q86V81 ALYREF
2
ALYREF [nucleoplasm]
(R-HSA-156649)
ALYREF [cytosol]
(R-HSA-158482)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.525
3
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.508
2
UniProt:Q96BD6 SPSB1
1
SPSB1 [cytosol]
(R-HSA-976024)
0.508
2
UniProt:Q5JVS0 HABP4
2
HABP4 [extracellular region]
(R-HSA-448329)
HABP4 [cytosol]
(R-HSA-448328)
0.508
2
UniProt:P63172 DYNLT1
3
DYNLT1 [secretory granule lumen]
(R-HSA-6801497)
DYNLT1 [extracellular region]
(R-HSA-6806509)
DYNLT1 [ficolin-1-rich granule lumen]
(R-HSA-6801487)
0.508
2
UniProt:Q5TAQ9 DCAF8
1
DCAF8 [nucleoplasm]
(R-HSA-8955192)
0.508
2
UniProt:Q99619 SPSB2
1
SPSB2 [cytosol]
(R-HSA-976048)
0.508
2
UniProt:Q01844 EWS
0.508
2
UniProt:O60506 HNRPQ
0.508
2
UniProt:Q8IZU1 FAM9A
0.508
2
UniProt:Q8IZS5 OFCC1
0.508
2
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.508
2
UniProt:P04591-PRO_0000038596 GAG
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
2
UniProt:Q14524 SCN5A
1
SCN5A [plasma membrane]
(R-HSA-443382)
0.471
2
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