Reactome | PRMT1 methylates ESRs

PRMT1 methylates ESRs

Stable Identifier

R-HSA-9632182

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ESR1 is methylated by PRMT1 at arginine 260 in response to E2 stimulation. Methylation is required for rapid non-genomic signaling by E2 and promotes the interaction of ESR1 with the p85 regulatory subunit of PI3K, SRC and PTK2 (FAK) (Simoncini et al, 2000; Le Romancer, 2008; reviewed in Arnal, 2017). Although this reaction is shown preceding palmitoylation of ESR1, the sequence of these two events is not established.

Literature References

PubMed ID	Title	Journal	Year
28539435	Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M	Physiol. Rev.	2017
11029009	Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase Liao, JK, Brazil, DP, Ley, K, Hafezi-Moghadam, A, Simoncini, T, Chin, WW	Nature	2000
18657504	Regulation of estrogen rapid signaling through arginine methylation by PRMT1 Leconte, N, Robin-Lespinasse, Y, Gobert-Gosse, S, Bouchekioua-Bouzaghou, K, Goddard, S, Corbo, L, Sentis, S, Treilleux, I, Le Romancer, M	Mol. Cell	2008