p16INK4A R58* [cytosol]

Stable Identifier
R-HSA-9632582
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p16INK4A R58TER, p16INK4A Arg58TER, p16INK4A Arg58*, CDKN2A R58TER, CDKN2A Arg58TER, CDKN2A R58*, CDKN2A Arg58*
p16INK4A R58* [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
9354451 CDKN2A/p16 is inactivated in most melanoma cell lines

Sparrow, LE, Gabrielli, BG, Parsons, PG, Pollock, PM, Castellano, M, Walters, MK, Down, LM, Hayward, NK

Cancer Res. 1997
External Reference Information
External Reference
Gene Names
CDKN2A, CDKN2, MTS1
Chain
chain:1-156
Other Identifiers
0002570204
0005130288
0101400494
1029
11718293_a_at
1713_s_at
207039_at
209644_x_at
211156_at
3201444
3201445
3201446
3201447
3201448
3201450
3201451
3201457
3201458
3201459
3201460
3201461
3201464
3201465
3201466
3201467
3201477
3201478
3201483
3201485
73132_r_at
8160441
A_23_P43484
A_23_P43490
A_33_P3411628
GE59038
GO:0000082
GO:0000278
GO:0001953
GO:0003674
GO:0003723
GO:0004861
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005694
GO:0005737
GO:0005829
GO:0006464
GO:0006950
GO:0007049
GO:0007050
GO:0007155
GO:0007165
GO:0007265
GO:0007568
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0016301
GO:0016310
GO:0019899
GO:0019901
GO:0022607
GO:0030234
GO:0030308
GO:0032088
GO:0034393
GO:0034641
GO:0035985
GO:0035986
GO:0040007
GO:0042326
GO:0043226
GO:0045736
GO:0045892
GO:0051059
GO:0051276
GO:0060260
GO:0090398
GO:0090399
GO:2000111
GO:2000134
GO:2000774
HMNXSV003019577
ILMN_1717714
ILMN_1757255
PH_hs_0019731
U26727_at
g1353569_3p_a_at
g1353569_3p_x_at
g4206166_3p_a_at
g4502748_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
L-arginine 58 replaced with unknown
Coordinate
58
PsiMod
A protein modification that effectively removes or replaces an L-arginine.
Disease
Name Identifier Synonyms
oral mucosa leukoplakia DOID:9655
chordoma DOID:3302 notochordoma
fibrous histiocytoma DOID:4415 benign fibrous histiocytoma, fibrous Histiocytoma, Fibroxanthoma
head and neck squamous cell carcinoma DOID:5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
lung squamous cell carcinoma DOID:3907 squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
ovarian cancer DOID:2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
pancreatic ductal adenocarcinoma DOID:3498 ductal adenocarcinoma of the pancreas
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
esophagus adenocarcinoma DOID:4914 Oesophageal adenocarcinoma, adenocarcinoma of esophagus
larynx cancer DOID:2596
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
bladder carcinoma DOID:4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
hepatocellular carcinoma DOID:684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
acute lymphocytic leukemia DOID:9952
lung adenocarcinoma DOID:3910 nonsmall cell adenocarcinoma
Barrett's esophagus DOID:9206 Barrett's ulcer of esophagus, Barrett's oesophagus, ulcerative esophagitis, Barrett's esophagus with esophagitis, Barrett esophagus, CLE, Barretts syndrome
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
vulva squamous cell carcinoma DOID:2101 squamous cell carcinoma of vulva, Vulvar Epidermoid carcinoma, vulvar squamous cell carcinoma
myeloma DOID:0070004
diffuse large B-cell lymphoma DOID:0050745
cervical squamous cell carcinoma DOID:3744 squamous cell carcinoma of the Cervix Uteri, squamous cell carcinoma of cervix
esophagus squamous cell carcinoma DOID:3748 SCC of esophagus, squamous cell carcinoma of esophagus
fibrosarcoma DOID:3355 Fibrocytic tumor, fibrous tissue neoplasm, fibrosarcoma of soft tissue
salivary gland cancer DOID:8850 malignant neoplasm of salivary gland NOS, malignant tumor of the Salivary gland, malignant neoplasm of salivary gland duct, malignant neoplasm of major salivary gland, NOS, malignant neoplasm of major salivary gland NOS (disorder), malignant neoplasm of major salivary gland NOS, malignant neoplasm of salivary gland, malignant neoplasm of salivary gland, unspecified, malignant tumor of salivary gland (disorder), malignant tumor of major salivary gland (disorder), malignant tumor of the Major Salivary gland, malignant neoplasm of major salivary gland, malignant neoplasm of other major salivary glands (disorder), malignant neoplasm of other major salivary glands
lung cancer DOID:1324
nasopharynx carcinoma DOID:9261 malignant neoplasm of nasopharynx, malignant neoplasm of anterior wall of nasopharynx, malignant neoplasm of lateral wall of nasopharynx, malignant tumor of lateral wall of nasopharynx, Nasopharyngeal carcinoma, carcinoma of nasopharynx, malignant tumor of posterior wall of nasopharynx, malignant Nasopharyngeal tumor, malignant neoplasm of posterior wall of nasopharynx, malignant neoplasm of nasopharyngeal wall, malignant neoplasm of other specified sites of nasopharynx, primary malignant neoplasm of anterior wall of nasopharynx, malignant tumor of anterior wall of nasopharynx, malignant neoplasm of roof of nasopharynx, malignant neoplasm of superior wall of nasopharynx, nasopharynx cancer
thymus cancer DOID:3277 thymus cancer, thymic neoplasm, Thymus cancer, Thymic tumor, neoplasm of thymus (disorder)
sebaceous carcinoma DOID:4840 malignant Sebaceous tumor, malignant neoplasm of sebaceous gland
skin squamous cell carcinoma DOID:3151 Epidermoid skin carcinoma, squamous cell carcinoma of skin (disorder)
cervical cancer DOID:4362 neoplasm of uterine cervix (disorder), tumor of the Cervix Uteri, cervix uteri cancer, cervical neoplasm, cervix cancer
basal cell carcinoma DOID:2513 malignant Basal cell neoplasm, malignant basal cell tumor, malignant basal cell tumor (morphologic abnormality), Basal cell cancer, BASAL CELL carcinoma OF SKIN, Rodent ulcer, Rodent ulcer, Basal cell carcinoma NOS (morphologic abnormality), Basal cell neoplasm NOS (morphologic abnormality), Rodent ulcer, basal cell carcinoma, Basal cell carcinoma (morphologic abnormality), Epithelioma basal cell (disorder), basal cell neoplasm, Basal cell neoplasm (morphologic abnormality), Basal cell tumor (morphologic abnormality), Rodent ulcer, Basal cell carcinoma of skin (disorder), Basal cell tumor
penis carcinoma DOID:3449 Penile carcinoma, carcinoma of penis (disorder)
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
epidermal appendage tumor DOID:2433 neoplasm of skin with adnexal differentiation, skin appendage tumour, neoplasm of the skin Appendage
oral squamous cell carcinoma DOID:0050866 mouth squamous cell carcinoma
stomach cancer DOID:10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
Interactors (12)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P11802 CDK4  3 0.952 16
 UniProt:Q00534 CDK6  3 0.934 15
 UniProt:P12004 PCNA  5 0.61 8
 UniProt:P02730 SLC4A1  8 0.602 5
 UniProt:O75496 GMNN  2 0.592 2
 UniProt:Q6UXH1 CREL2      0.508 2
 UniProt:Q00839 HNRNPU  1 0.508 2
 UniProt:Q8NHU6 TDRD7      0.508 2
 UniProt:O75398 DEAF1      0.508 2
 UniProt:Q14566 MCM6  1 0.499 4
 UniProt:P24385 CCND1  4 0.491 2
 UniProt:P62826 RAN  2 0.463 2
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