p16INK4A W110* [cytosol]

Stable Identifier
R-HSA-9632585
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p16INK4A W110TER, p16INK4A Trp110TER, p16INK4A Trp110*, CDKN2A W110TER, CDKN2A Trp110TER, CDKN2A W110*, CDKN2A Trp110*
p16INK4A W110* [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
9354451 CDKN2A/p16 is inactivated in most melanoma cell lines

Sparrow, LE, Gabrielli, BG, Parsons, PG, Pollock, PM, Castellano, M, Walters, MK, Down, LM, Hayward, NK

Cancer Res. 1997
External Reference Information
External Reference
Gene Names
CDKN2A, CDKN2, MLM, MTS1
Chain
chain:1-156
Other Identifiers
1029
11718293_a_at
11753744_a_at
11753745_x_at
1713_s_at
207039_PM_at
207039_at
209644_PM_x_at
209644_x_at
211156_PM_at
211156_at
3201444
3201445
3201446
3201447
3201448
3201450
3201451
3201452
3201453
3201454
3201455
3201456
3201457
3201458
3201459
3201460
3201461
3201464
3201465
3201466
3201467
3201472
3201473
3201474
3201477
3201478
3201480
3201481
3201483
3201485
49757_at
73130_s_at
73132_r_at
8160441
A_23_P43484
A_23_P43490
A_33_P3411628
GE59038
GE897374
GO:0000209
GO:0001953
GO:0002039
GO:0003677
GO:0003723
GO:0003824
GO:0004861
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0006355
GO:0006364
GO:0006915
GO:0006919
GO:0007005
GO:0007265
GO:0008285
GO:0008637
GO:0010628
GO:0012501
GO:0016604
GO:0016740
GO:0016925
GO:0019789
GO:0019901
GO:0030308
GO:0030575
GO:0030889
GO:0031647
GO:0031648
GO:0032088
GO:0032991
GO:0033088
GO:0033235
GO:0034393
GO:0034504
GO:0035985
GO:0042326
GO:0043065
GO:0043226
GO:0043517
GO:0045736
GO:0045892
GO:0045893
GO:0045944
GO:0046825
GO:0048103
GO:0050821
GO:0051059
GO:0051444
GO:0051726
GO:0055105
GO:0061629
GO:0070534
GO:0090398
GO:0090399
GO:0097371
GO:0097718
GO:0098772
GO:0140096
GO:1900182
GO:1901798
GO:1902510
GO:1902570
GO:1904667
GO:1990000
GO:1990948
GO:2000045
GO:2000059
GO:2000111
GO:2000435
HMNXSV003019577
ILMN_1717714
ILMN_1744295
ILMN_1757255
PH_hs_0019731
PH_hs_0039700
U26727_at
g1353569_3p_a_at
g1353569_3p_x_at
g4206166_3p_a_at
g4502748_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
Nonsense mutation at L-tryptophan 110
Coordinate
110
PsiMod
A protein modification that effectively removes or replaces an L-tryptophan.
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
sebaceous carcinoma DOID:4840 malignant Sebaceous tumor, malignant neoplasm of sebaceous gland
vulva squamous cell carcinoma DOID:2101 squamous cell carcinoma of vulva, Vulvar Epidermoid carcinoma, vulvar squamous cell carcinoma
thyroid carcinoma DOID:3963 head and neck cancer, Thyroid
fibrous histiocytoma DOID:4415 benign fibrous histiocytoma, fibrous Histiocytoma, Fibroxanthoma
thymus cancer DOID:3277 thymus cancer, thymic neoplasm, Thymus cancer, Thymic tumor, neoplasm of thymus (disorder)
head and neck squamous cell carcinoma DOID:5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
larynx cancer DOID:2596
bladder carcinoma DOID:4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
oral squamous cell carcinoma DOID:0050866 mouth squamous cell carcinoma
kidney cancer DOID:263 malignant neoplasm of kidney except pelvis, malignant tumour of kidney, renal cancer
skin squamous cell carcinoma DOID:3151 Epidermoid skin carcinoma, squamous cell carcinoma of skin (disorder)
lung squamous cell carcinoma DOID:3907 squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
Barrett's esophagus DOID:9206 Barrett's ulcer of esophagus, Barrett's oesophagus, ulcerative esophagitis, Barrett's esophagus with esophagitis, Barrett esophagus, CLE, Barretts syndrome
esophagus squamous cell carcinoma DOID:3748 SCC of esophagus, squamous cell carcinoma of esophagus
stomach cancer DOID:10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
bile duct carcinoma DOID:4897
trachea squamous cell carcinoma DOID:12003 Tracheal Epidermoid carcinoma, squamous cell carcinoma of trachea
pharynx squamous cell carcinoma DOID:0050921
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
lung cancer DOID:1324
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
acute lymphocytic leukemia DOID:9952
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
pancreatic ductal adenocarcinoma DOID:3498 ductal adenocarcinoma of the pancreas
esophagus adenocarcinoma DOID:4914 Oesophageal adenocarcinoma, adenocarcinoma of esophagus
astrocytoma DOID:3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
Interactors (12)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P11802 CDK4  3 0.96 19
 UniProt:Q00534 CDK6  3 0.949 19
 UniProt:P12004 PCNA  5 0.61 8
 UniProt:P02730 SLC4A1  8 0.602 5
 UniProt:O75496 GMNN  2 0.592 2
 UniProt:Q6UXH1 CREL2      0.508 2
 UniProt:Q00839 HNRNPU  1 0.508 2
 UniProt:Q8NHU6 TDRD7      0.508 2
 UniProt:O75398 DEAF1      0.508 2
 UniProt:Q14566 MCM6  1 0.499 4
 UniProt:P24385 CCND1  4 0.491 2
 UniProt:P62826 RAN  2 0.463 2
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