Reactome | PRKCZ recruits RAS in response to estrogen stimulation

PRKCZ recruits RAS in response to estrogen stimulation

Stable Identifier

R-HSA-9632906

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PRKCZ recruits RAS in response to estrogen stimulation

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RAS is recruited to a complex that also contains SRC, PRKCZ and the p85 subunit of PI3K in response to estrogen stimulation (Castoria et al, 2004). RAS signaling downstream of ESR1 contributes to cell cycle progression through the induction of cyclin D transcription and the nuclear export of CDKN1B (Castoria et al, 1999; Castoria et al, 2001; Migliaccio et al, 1996; Rodier et al, 2002; reviewed in Castoria et al, 2010; Arnal et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
28539435	Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M	Physiol. Rev.	2017
15314172	Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells Auricchio, F, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L	Mol. Cell. Biol.	2004
8635462	Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells Auricchio, F, Bontempo, P, Di Domenico, M, de Falco, A, Nola, E, Castoria, G, Migliaccio, A	EMBO J.	1996
19879889	Cell proliferation regulated by estradiol receptor: Therapeutic implications Auricchio, F, Giovannelli, P, Castoria, G, Migliaccio, A	Steroids	2010
10228164	Non-transcriptional action of oestradiol and progestin triggers DNA synthesis Auricchio, F, Migliaccio, A, Castoria, G, Di Domenico, M, Barone, MV, Bilancio, A, Ametrano, D	EMBO J.	1999
11726503	p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis Meloche, S, Coulombe, P, Rodier, G, Montagnoli, A, Di Marcotullio, L, Pagano, M, Draetta, GF	EMBO J.	2001
11689445	PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L	EMBO J.	2001