Reactome | ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

Stable Identifier

R-HSA-9632910

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MAPK1 (also known as ERK2) translocates to the nucleus in response to estrogen stimulation several cell lines in a manner that also depends on SRC, PI3K and PRCKZ (Castoria et al, 2004). RAS signaling and ERK2 nuclear translocation promotes estrogen-dependent stimulation of cell cycle progression (Castoria et al, 1999; Castoria et al, 2001; Migliaccio et al, 1996; Castoria et al, 2004; Rodier et al, 2002; Foster et al, 2003;reviewed in Castoria et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
15314172	Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells Castoria, G, Migliaccio, A, Di Domenico, M, Lombardi, M, de Falco, A, Varricchio, L, Bilancio, A, Barone, MV, Auricchio, F	Mol. Cell. Biol.	2004
12904306	Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway Foster, JS, Fernando, RI, Ishida, N, Nakayama, KI, Wimalasena, J	J. Biol. Chem.	2003
8635462	Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells Migliaccio, A, Di Domenico, M, Castoria, G, de Falco, A, Bontempo, P, Nola, E, Auricchio, F	EMBO J.	1996
19879889	Cell proliferation regulated by estradiol receptor: Therapeutic implications Castoria, G, Migliaccio, A, Giovannelli, P, Auricchio, F	Steroids	2010
10228164	Non-transcriptional action of oestradiol and progestin triggers DNA synthesis Castoria, G, Barone, MV, Di Domenico, M, Bilancio, A, Ametrano, D, Migliaccio, A, Auricchio, F	EMBO J.	1999
11726503	p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis Rodier, G, Montagnoli, A, Di Marcotullio, L, Coulombe, P, Draetta, GF, Pagano, M, Meloche, S	EMBO J.	2001
11689445	PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells Castoria, G, Migliaccio, A, Bilancio, A, Di Domenico, M, de Falco, A, Lombardi, M, Fiorentino, R, Varricchio, L, Barone, MV, Auricchio, F	EMBO J.	2001