Reactome | ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

Stable Identifier

R-HSA-9632910

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

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MAPK1 (also known as ERK2) translocates to the nucleus in response to estrogen stimulation several cell lines in a manner that also depends on SRC, PI3K and PRCKZ (Castoria et al, 2004). RAS signaling and ERK2 nuclear translocation promotes estrogen-dependent stimulation of cell cycle progression (Castoria et al, 1999; Castoria et al, 2001; Migliaccio et al, 1996; Castoria et al, 2004; Rodier et al, 2002; Foster et al, 2003;reviewed in Castoria et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
15314172	Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells Auricchio, F, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L	Mol. Cell. Biol.	2004
12904306	Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway Foster, JS, Fernando, RI, Wimalasena, J, Nakayama, KI, Ishida, N	J. Biol. Chem.	2003
8635462	Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells Auricchio, F, Bontempo, P, Di Domenico, M, de Falco, A, Nola, E, Castoria, G, Migliaccio, A	EMBO J.	1996
19879889	Cell proliferation regulated by estradiol receptor: Therapeutic implications Auricchio, F, Giovannelli, P, Castoria, G, Migliaccio, A	Steroids	2010
10228164	Non-transcriptional action of oestradiol and progestin triggers DNA synthesis Auricchio, F, Migliaccio, A, Castoria, G, Di Domenico, M, Barone, MV, Bilancio, A, Ametrano, D	EMBO J.	1999
11726503	p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis Meloche, S, Coulombe, P, Rodier, G, Montagnoli, A, Di Marcotullio, L, Pagano, M, Draetta, GF	EMBO J.	2001
11689445	PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L	EMBO J.	2001