EIF2AK4 (GCN2) dimer autophosphorylates

Stable Identifier
R-HSA-9633742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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EIF2AK4 (GCN2) dimer autophosphorylates
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After binding uncharged tRNA, the EIF2AK4 (GCN2) dimer trans-autophosphorylates on threonine-899, resulting in activation of the kinase domain of EIF2AK4 (Harding et al. 2000, Deng et al. 2002, Cambiaghi et al. 2014, and inferred from mouse homologs and yeast homologs).

Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol]

Physical Entity
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Eif2ak4 dimer autophosphorylates (Mus musculus)
GCN2 dimer autophosphorylates (Saccharomyces cerevisiae)
Authored
May, B  (2018-12-29)
Reviewed
Staschke, KA  (2019-11-20)
Bruhat, A  (2019-09-15)
Created
May, B  (2018-12-31)
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