POM121 and NDC1 bind the Nup93 complex

Stable Identifier
R-HSA-9634169
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, nuclear envelope
ReviewStatus
5/5
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POM121 and NDC1 bind the Nup93 complex
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From studies with Xenopus and human model systems, the transmembrane nucleoporins POM121 and NDC1 recruit the NUP93 complex to nascent nuclear pore complexes (NPCs) due to interaction with the NUP93 complex components NUP155 (Mitchell et al. 2010) and, potentially, NUP35 (Mansfield et al. 2006). This is consistent with order-of-assembly seen in live cell imaging (Dultz et al. 2008).
Literature References
PubMed ID Title Journal Year
20974814 Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane

Capitanio, J, Mitchell, JM, Wozniak, RW, Mansfeld, J, Kutay, U

J. Cell Biol. 2010
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Orthologous Events
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POM121 and NDC1 bind the Nup93 complex (Drosophila melanogaster)
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POM121 and NDC1 bind the Nup93 complex (Schizosaccharomyces pombe)
POM121 and NDC1 bind the Nup93 complex (Sus scrofa)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2019-01-07)
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