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Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer
Stable Identifier
R-HSA-9634402
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Both GRB2 and SHC1 are recruited to autophosphorylated ERBB2 homodimers (Pickl and Ries 2009). It is assumed, by analogy to the behavior of normal ERBB2 heterodimers, that GRB2 is recruited to ERBB2 homodimers through SHC1, and that GRB2 is in complex with SOS1.
Literature References
PubMed ID
Title
Journal
Year
18978815
Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
Pickl, M
,
Ries, CH
Oncogene
2009
Participants
Input
GRB2-1:SOS1 [cytosol]
(Homo sapiens)
p-ERBB2 homodimer:p-Y349,Y350-SHC1 [plasma membrane]
(Homo sapiens)
Output
p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
Normal reaction
Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
(Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M (2019-07-31)
Reviewed
Kancha, RK (2019-09-16)
Created
Orlic-Milacic, M (2019-01-10)
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