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p-Y565,S797-HIF1A [cytosol]
Stable Identifier
R-HSA-9634700
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:Q15369 ELOC
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 promotes HIF1A stabilization (Homo sapiens)
LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)
p-Y565,S797-HIF1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16665 HIF1A
Gene Names
HIF1A, BHLHE78, MOP1, PASD8
Chain
chain:1-826
Reference Genes
BioGPS Gene:3091 HIF1A
COSMIC (genes):HIF1A HIF1A
CTD Gene:3091 HIF1A
dbSNP Gene:3091 HIF1A
ENSEMBL:ENSG00000100644 HIF1A
ENSEMBL_homo_sapiens_GENE:ENSG00000100644.17 HIF1A
HGNC:4910 HIF1A
KEGG Gene (Homo sapiens):3091 HIF1A
Monarch:3091 HIF1A
NCBI Gene:3091 HIF1A
OMIM:603348 HIF1A
UCSC:Q16665 HIF1A
Reference Transcript
RefSeq:NM_001243084.1 HIF1A
RefSeq:NM_181054.2 HIF1A
RefSeq:NM_001530.3 HIF1A
Other Identifiers
1039_s_at
11718757_s_at
11718758_a_at
11718759_x_at
11747800_a_at
11749123_a_at
11749648_a_at
11749649_x_at
11755737_x_at
16785058
200989_PM_at
200989_at
3091
3539073
3539074
3539075
3539083
3539084
3539085
3539087
3539088
3539089
3539090
3539091
3539093
3539094
3539095
3539097
3539098
3539099
3539100
3539102
3539103
3539104
3539105
75276_at
7974851
A_14_P117087
A_24_P56388
A_33_P3231277
GE59057
GO:0000302
GO:0000785
GO:0000791
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001216
GO:0001217
GO:0001223
GO:0001228
GO:0001525
GO:0001568
GO:0001666
GO:0001678
GO:0001755
GO:0001837
GO:0001892
GO:0001922
GO:0001938
GO:0001944
GO:0001947
GO:0002039
GO:0002052
GO:0002062
GO:0002067
GO:0002071
GO:0002248
GO:0002376
GO:0003151
GO:0003208
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005929
GO:0005975
GO:0006089
GO:0006091
GO:0006110
GO:0006351
GO:0006355
GO:0006357
GO:0006879
GO:0006914
GO:0006915
GO:0006954
GO:0007005
GO:0007018
GO:0007165
GO:0007405
GO:0007595
GO:0008542
GO:0010039
GO:0010468
GO:0010508
GO:0010573
GO:0010575
GO:0010628
GO:0010629
GO:0010634
GO:0012501
GO:0014850
GO:0016239
GO:0016604
GO:0016607
GO:0016922
GO:0019896
GO:0019899
GO:0019901
GO:0019904
GO:0021502
GO:0021987
GO:0023052
GO:0030154
GO:0030279
GO:0030282
GO:0030502
GO:0030949
GO:0031514
GO:0031625
GO:0031929
GO:0032007
GO:0032364
GO:0032722
GO:0032909
GO:0032963
GO:0032991
GO:0034599
GO:0035162
GO:0035773
GO:0035774
GO:0036211
GO:0042060
GO:0042127
GO:0042541
GO:0042593
GO:0042826
GO:0043066
GO:0043226
GO:0043524
GO:0043536
GO:0043565
GO:0045648
GO:0045766
GO:0045821
GO:0045893
GO:0045926
GO:0045944
GO:0046716
GO:0046886
GO:0046982
GO:0046983
GO:0048514
GO:0048546
GO:0048593
GO:0048856
GO:0048870
GO:0050877
GO:0051000
GO:0051216
GO:0051402
GO:0051541
GO:0051879
GO:0055065
GO:0055086
GO:0060574
GO:0061030
GO:0061072
GO:0061298
GO:0061629
GO:0070101
GO:0070243
GO:0070244
GO:0070888
GO:0071347
GO:0071456
GO:0071542
GO:0090575
GO:0097152
GO:0097411
GO:0098586
GO:0098772
GO:0140110
GO:0140537
GO:1900017
GO:1901135
GO:1901526
GO:1902894
GO:1902895
GO:1903377
GO:1903715
GO:1904115
GO:2000273
GO:2000378
GO:2000434
GO:2001054
HMNXSV003055761
ILMN_1681283
ILMN_1763260
ILMN_2379788
PH_hs_0028366
TC14002197.hg
U22431_s_at
g4504384_3p_at
Participates
as an output of
LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)
Other forms of this molecule
HN-HIF1A [cytosol]
2xHP-HIF1A [nucleoplasm]
2xHP-HIF1A [cytosol]
p-Y565-HIF1A [cytosol]
HIF1A [cytosol]
HIF1A [nucleoplasm]
Inferred To
phospho-HIF1A [cytosol]
(Bos taurus)
phospho-HIF1A [cytosol]
(Canis familiaris)
phospho-HIF1A [cytosol]
(Sus scrofa)
phospho-Hif1a [cytosol]
(Mus musculus)
phospho-Hif1a [cytosol]
(Rattus norvegicus)
phospho-hif-1 [cytosol]
(Caenorhabditis elegans)
phospho-sima [cytosol]
(Drosophila melanogaster)
phospho-hif1a [cytosol]
(Xenopus tropicalis)
phospho-p-Y565,S797-HIF1A [cytosol]
(Gallus gallus)
phospho-hif1ab [cytosol]
(Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 565
Coordinate
565
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 797
Coordinate
797
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001521.1
,
NP_001230013.1
,
NP_851397.1
ZINC - World Drugs
HIF1A_HUMAN
OpenTargets
ENSG00000100644
ZINC - FDA approved
HIF1A_HUMAN
ZINC - Substances
HIF1A_HUMAN
ZINC - Biogenic
HIF1A_HUMAN
ZINC target
Q16665
PRO
Q16665
PDB
1L8C
,
1H2M
,
6GFX
,
5LAS
,
2ILM
,
3HQU
,
6GMR
,
5L9B
,
5LA9
,
4AJY
,
1H2L
,
8HE3
,
4H6J
,
1H2K
,
1LM8
,
7LVS
,
7QGS
,
5L9V
,
8HE0
,
3HQR
,
1LQB
,
1L3E
,
5JWP
,
6YW3
ZINC - Metabolites
HIF1A_HUMAN
HPA
ENSG00000100644-HIF1A
GeneCards
Q16665
Ensembl
ENST00000539097
,
ENST00000337138
,
ENSP00000437955
,
ENSP00000323326
,
ENSG00000100644
,
ENST00000323441
,
ENSP00000338018
Pharos - Targets
Q16665
ZINC - Predictions - Purchasable
HIF1A_HUMAN
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.962
22
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.962
20
UniProt:P27540 ARNT
1
ARNT [nucleoplasm]
(R-HSA-1234098)
0.936
13
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.922
12
UniProt:Q9H6Z9 EGLN3
2
EGLN3 [nucleoplasm]
(R-HSA-1234104)
EGLN3 [cytosol]
(R-HSA-1234115)
0.881
7
UniProt:Q9GZT9 EGLN1
1
EGLN1 [cytosol]
(R-HSA-1234108)
0.803
5
UniProt:Q15370 ELOB
2
TCEB2 [nucleoplasm]
(R-HSA-112423)
ELOB [cytosol]
(R-HSA-180551)
0.789
8
IntAct:EBI-2895491 VEGFA
0.725
6
UniProt:O60224 SSX4
0.721
5
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.702
5
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.688
4
UniProt:Q96KS0 EGLN2
1
EGLN2 [nucleoplasm]
(R-HSA-1234117)
0.683
3
UniProt:O00257 CBX4
2
monoSUMO1-K494-CBX4 [nucleoplasm]
(R-HSA-4551626)
CBX4 [nucleoplasm]
(R-HSA-389118)
0.674
15
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.669
3
UniProt:P41227 NAA10
0.667
3
UniProt:P40337-3 VHL
0.659
6
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.649
9
UniProt:Q8N461 FBXL16
1
FBXL16 [cytosol]
(R-HSA-8862609)
0.615
6
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.609
2
UniProt:P09467 FBP1
1
FBP1 [cytosol]
(R-HSA-70476)
0.602
5
UniProt:P14618-1 PKM
2
PolyUb-PKM-1 [cytosol]
(R-HSA-9861692)
PKM-1 [cytosol]
(R-HSA-71667)
0.591
7
UniProt:P17861 XBP1
0.591
3
UniProt:P25789 PSMA4
2
PSMA4 [nucleoplasm]
(R-HSA-174324)
PSMA4 [cytosol]
(R-HSA-68730)
0.576
4
UniProt:P11474 ESRRA
1
ESRRA [nucleoplasm]
(R-HSA-446159)
0.576
3
UniProt:MAFG Q9BRP3
0.557
3
UniProt:Q9UHD8-1 SEPTIN9
0.556
4
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.556
6
UniProt:Q9HBZ2 ARNT2
1
ARNT2 [nucleoplasm]
(R-HSA-8936838)
0.547
2
UniProt:P40818 USP8
2
USP8 [cytosol]
(R-HSA-917720)
p-T945-USP8 [cytosol]
(R-HSA-1358714)
0.544
2
UniProt:O14818 PSMA7
2
PSMA7 [nucleoplasm]
(R-HSA-174351)
PSMA7 [cytosol]
(R-HSA-68736)
0.544
2
UniProt:P51450-2 Rorc
1
Rorc-2 [nucleoplasm]
(R-MMU-8949302)
0.544
2
UniProt:Q8BIF2 Rbfox3
1
Rbfox3 [nucleoplasm]
(R-MMU-9770531)
0.544
2
UniProt:P12882 MYH1
0.527
2
UniProt:P13533 MYH6
1
MYH6 [cytosol]
(R-HSA-390563)
0.527
2
UniProt:Q9UKX2 MYH2
1
MYH2 [cytosol]
(R-HSA-1449561)
0.527
2
UniProt:P11055 MYH3
1
MYH3 [cytosol]
(R-HSA-390560)
0.527
2
UniProt:Q9Y623 MYH4
0.527
2
UniProt:P68133 ACTA1
1
ACTA1 [cytosol]
(R-HSA-390534)
0.527
2
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.524
2
UniProt:Q96CJ1 EAF2
1
EAF2 [nucleoplasm]
(R-HSA-8932790)
0.524
3
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.524
3
UniProt:Q5RIX9
1
e2f7 [nucleoplasm]
(R-DRE-6798305)
0.524
2
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.524
3
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.499
2
UniProt:Q9C0J9 BHLHE41
1
BHLHE41 [nucleoplasm]
(R-HSA-879703)
0.499
2
UniProt:Q9Y2N7-4 HIF3A
0.499
2
UniProt:Q61539
1
Esrrb [nucleoplasm]
(R-MMU-446173)
0.499
2
UniProt:Q99PV5 Bhlhe41
1
Bhlhe41 [nucleoplasm]
(R-MMU-879802)
0.499
3
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.499
3
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.463
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.463
6
UniProt:P49327 FASN
3
FASN [cytosol]
(R-HSA-199233)
decanoyl-FASN [cytosol]
(R-HSA-5655935)
FASN [cytosol]
(R-HSA-54659)
0.463
4
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