CDK5 gene expression is stimulated by NPAS4

Stable Identifier
R-HSA-9634916
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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CDK5 gene expression is stimulated by NPAS4
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Based on studies in mouse, NPAS4 directly stimulates expression of the CDK5 gene, encoding cyclin-dependent-like kinase 5 (Yun et al. 2013), a serine/threonine protein kinase which is essential for neuronal cell cycle exit and differentiation. In primary cultures of rat neurons, Cdk5 gene expression was not significantly changed upon Npas4 activation (Brigidi et al. 2019).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):CDK5 gene [nucleoplasm] (Homo sapiens)
Active Unit
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2) [nucleoplasm]
Inferred From
Cdk5 gene expression is stimulated by Npas4 (Mus musculus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-01-16)
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