MyrG-CDK5R1 binds CDK5

Stable Identifier
R-HSA-9634943
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MyrG-CDK5R1 binds CDK5
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CDK5R1 is a neuron-specific regulatory subunit of CDK5 that activates CDK5 kinase activity in a cyclin-type manner and CDK5R1 and CDK5 co-precipitate from rat PC12 cells and from bovine brain (Tsai et al, 1994; Lew et al, 1994; Harada et al, 2001). CDK5 activity is required for neurite outgrowth and disruption of CDK5 or CDK5R1 leads to defects in neuronal migration in mice (Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998).
Participants
Input
Output
Participates
as an event of
Inferred From
MyrG-Cdk5r1(2-307) binds Cdk5 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-01-17)
Cite Us!