Reactome | CTSG [cytosol]

CTSG [cytosol]

Stable Identifier

R-HSA-9635429

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cathepsin G, CATG_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9BYJ9 YTHD1

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Suppression of apoptosis (Homo sapiens)
        
        Rv3364c binds cathepsin G (Homo sapiens)
        
        CTSG [cytosol] (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        CTSG cleaves CASP1(1-404) (Homo sapiens)
        
        CTSG [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 processing (Homo sapiens)
        
        CTSG cleaves CASP1(1-404) (Homo sapiens)
        
        CTSG [cytosol] (Homo sapiens)

General

After secretion Cathepsin G is extracellular and associated with the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
2681419	Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity Campbell, MA, Silverman, EK, Campbell, EJ	J Immunol	1989

External Reference Information

External Reference

UniProt:P08311 CTSG

Gene Names

CTSG

Chain

signal peptide:1-18, propeptide:19-20, chain:21-244, chain:21-243, propeptide:245-255

Reference Genes

BioGPS Gene:1511 CTSG

COSMIC (genes):CTSG CTSG

CTD Gene:1511 CTSG

dbSNP Gene:1511 CTSG

ENSEMBL:ENSG00000100448 CTSG

HGNC:2532 CTSG

KEGG:hsa:1511 CTSG

Monarch:1511 CTSG

NCBI Gene:1511 CTSG

OMIM:116830 CTSG

UCSC:P08311 CTSG

Reference Transcript

RefSeq:NM_001911.2 CTSG

Other Identifiers

11723339_at

1511

16791427

205653_PM_at

205653_at

3558348

3558349

3558350

3558352

3558353

3558354

3558357

3558358

37105_at

679_at

7978351

A_23_P140384

GE57841

GO:0002003

GO:0002376

GO:0002548

GO:0003824

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005886

GO:0006468

GO:0006508

GO:0006935

GO:0006955

GO:0008201

GO:0008233

GO:0008236

GO:0010494

GO:0016020

GO:0016485

GO:0016787

GO:0019221

GO:0019731

GO:0022617

GO:0030141

GO:0030168

GO:0030198

GO:0030312

GO:0031012

GO:0031410

GO:0032496

GO:0035578

GO:0035590

GO:0042119

GO:0042742

GO:0043226

GO:0043231

GO:0048018

GO:0048870

GO:0050778

GO:0050829

GO:0050830

GO:0050832

GO:0050868

GO:0051604

GO:0062023

GO:0070062

GO:0070946

GO:0071222

GO:0089720

GO:0098542

GO:0098772

GO:0098786

GO:0140096

GO:1901731

HMNXSV003047913

ILMN_1680424

J04990_at

TC14000980.hg

g4503148_3p_at

Participates

as a component of

Rv3364c:CTSG [cytosol] (Homo sapiens)

as an input of

Rv3364c binds cathepsin G (Homo sapiens)

Other forms of this molecule

CTSG [extracellular region]

CTSG [plasma membrane]

CTSG [azurophil granule lumen]

Inferred To

LOC100154047 [cytosol] (Sus scrofa)

LOC509956 [cytosol] (Bos taurus)

CTSG [cytosol] (Canis familiaris)

Ctsg [cytosol] (Mus musculus)

Ctsg [cytosol] (Rattus norvegicus)

ctsg [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001902.1

ZINC - World Drugs

CATG_HUMAN

Guide to Pharmacology - Targets

2348

OpenTargets

ENSG00000100448

ENSEMBL

ENSP00000216336, ENST00000216336

ZINC - FDA approved

CATG_HUMAN

ZINC - Substances

CATG_HUMAN

ZINC - Biogenic

CATG_HUMAN

ZINC target

P08311

PRO

P08311

GlyGen

P08311

PDB

1CGH, 8G24, 9ASX, 1AU8, 6VTM, 8G26, 1KYN, 8G25, 8D4V, 8D7I, 9ATK, 1T32, 8D4S, 8D7K

ZINC - Investigational

CATG_HUMAN

IntEnz

3.4.21.20

HPA

ENSG00000100448-CTSG

Pharos - Targets

P08311

ZINC - Predictions - Purchasable

CATG_HUMAN

HMDB Protein

HMDBP14055

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q96D09 GASP2			0.527	2
UniProt:Q659A1 ICE2	1	ICE2 [nucleoplasm] (R-HSA-6807421)	0.527	2
UniProt:O95785 WIZ			0.527	2
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) RPS27A(1-76) [cytosol] (R-HSA-939205) p-S65-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834951) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834993) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-11-RPS27A(1-76) [cytosol] (R-HSA-3095933)	0.527	2
UniProt:Q9BYJ9 YTHD1			0.527	2
UniProt:Q9BQ70 TCF25			0.527	2