PtpA dephosphorylates GSK3A

Stable Identifier
R-HSA-9635461
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
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PtpA dephosphorylates GSK3A
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Mtb infection inhibits the cleavage of inactive caspase-3 into its active forms by dephosphorylation of human glycogen synthase kinase-3 alpha (GSK3α). Tyr-279 is essential for the full activity of GSK3α. Mtb protein tyrosine phosphatase (PtpA) dephosphorylates Tyr-279 and thereby inactivates GSK3α (Poirier et al. 2014).

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Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PtpA [cytosol]

Physical Entity
PtpA [cytosol] (Mycobacterium tuberculosis)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-12)
Reviewed
Deffur, A  (2019-10-23)
Wilkinson, RJ  (2019-10-23)
Created
Pardo, AM  (2019-02-05)
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