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Suppression of apoptosis
Stable Identifier
R-HSA-9635465
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of apoptosis (Homo sapiens)
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In order to survive and grow within the phagocyte, Mtb has to inhibit programmed cell death. Several proteins are secreted by Mtb that block different pathways leading to complete arrest of apoptosis (Moraco & Kornfeld 2014).
Literature References
PubMed ID
Title
Journal
Year
25453227
Cell death and autophagy in tuberculosis
Kornfeld, H
,
Moraco, AH
Semin. Immunol.
2014
Participants
Events
PtpA dephosphorylates GSK3A
(Homo sapiens)
Rv3364c binds cathepsin G
(Homo sapiens)
Rv3654c binds SFPQ
(Homo sapiens)
Rv3655c binds RNF213
(Homo sapiens)
PtpA binds TRIM27
(Homo sapiens)
Mce3E binds MAPK3
(Homo sapiens)
Mce3E binds MAPK1
(Homo sapiens)
Participates
as an event of
Response of Mtb to phagocytosis (Homo sapiens)
Event Information
Go Biological Process
negative regulation by symbiont of host apoptotic process (0033668)
Disease
Name
Identifier
Synonyms
tuberculosis
DOID:399
tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R (2019-02-12)
Reviewed
Wilkinson, RJ (2019-10-23)
Deffur, A (2019-10-23)
Created
Pardo, AM (2019-02-05)
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