Reactome | SFPQ [cytosol]

SFPQ [cytosol]

Stable Identifier

R-HSA-9635505

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Splicing factor, proline- and glutamine-rich, SFPQ_HUMAN, PSF

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Suppression of apoptosis (Homo sapiens)
        
        Rv3654c binds SFPQ (Homo sapiens)
        
        Rv3654c:SFPQ [cytosol] (Homo sapiens)
        
        SFPQ [cytosol] (Homo sapiens)
        
        SFPQ [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23246 SFPQ

Gene Names

SFPQ, PSF

Chain

chain:1-707

Reference Genes

BioGPS Gene:6421 SFPQ

COSMIC (genes):SFPQ SFPQ

CTD Gene:6421 SFPQ

dbSNP Gene:6421 SFPQ

ENSEMBL:ENSG00000116560 SFPQ

ENSEMBL:ENSG00000116560.12 SFPQ

HGNC:10774 SFPQ

KEGG Gene (Homo sapiens):6421 SFPQ

Monarch:6421 SFPQ

NCBI Gene:6421 SFPQ

OMIM:605199 SFPQ

UCSC:P23246 SFPQ

Reference Transcript

Other Identifiers

11720474_a_at

11720475_x_at

16685076

201585_PM_s_at

201585_s_at

201586_PM_s_at

201586_s_at

2406078

2406079

2406080

2406081

2406082

2406083

2406089

2406091

2406093

2406094

2406095

2406096

2406098

2406100

2406101

2406102

2406103

2406104

40638_at

41199_s_at

54981_r_at

6421

76096_at

7914791

A_33_P3318292

GE61121

GO:0000122

GO:0000380

GO:0000724

GO:0000785

GO:0000976

GO:0002218

GO:0002376

GO:0003676

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006397

GO:0006974

GO:0008380

GO:0012501

GO:0016071

GO:0016363

GO:0016607

GO:0023052

GO:0042382

GO:0042752

GO:0042754

GO:0042803

GO:0042826

GO:0043226

GO:0045087

GO:0045892

GO:0045944

GO:0048511

GO:0090575

GO:0098542

GO:1902177

HMNXSV003010292

HMNXSV003044369

Hs.180610.3.A1_3p_a_at

ILMN_1769931

PH_hs_0027942

X70944_s_at

g4826997_3p_a_at

Participates

as a component of

Rv3654c:SFPQ [cytosol] (Homo sapiens)

as an input of

Rv3654c binds SFPQ (Homo sapiens)

Other forms of this molecule

p-Y-SFPQ [nucleoplasm]

SFPQ [nucleoplasm]

Cross References

RefSeq

XP_005271169.1, XP_005271172.1, NP_005057.1, XP_016857543.1, XP_005271170.1, XP_016857542.1

OpenTargets

ENSG00000116560

HPA

ENSG00000116560-SFPQ

GeneCards

P23246

Ensembl

ENSP00000349748, ENST00000357214, ENSG00000116560

PRO

P23246

Pharos - Targets

P23246

Orphanet

21871

HMDB Protein

HMDBP01953

PDB

4WIK, 6WMZ, 7LRQ, 7SP0, 7LRU, 4WII, 5WPA, 7PU5, 6NCQ, 7UJ1, 7UK1, 4WIJ, 6OWJ

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15233 NONO			0.742	5
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.702	4
UniProt:Q06787 FMR1			0.667	3
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342-PTK6 [cytosol] (R-HSA-8848007) PTK6 [cytosol] (R-HSA-8848000)	0.632	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.591	4
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.576	6
UniProt:O60861 GAS7			0.564	2
UniProt:Q68DV7 RNF43	10	RNF43 E174* [plasma membrane] (R-HSA-5340574) RNF43 R330fs89 [plasma membrane] (R-HSA-5340581) RNF43 A169T [plasma membrane] (R-HSA-9666639) RNF43 R117Afs41 [plasma membrane] (R-HSA-9666664) RNF43 R132* [plasma membrane] (R-HSA-9666650) RNF43 P154L [plasma membrane] (R-HSA-9666646) RNF43 F69C [plasma membrane] (R-HSA-5340578) RNF43 [plasma membrane] (R-HSA-5323531) ub-RNF43 [plasma membrane] (R-HSA-5323547) RNF43 G659Vfs*41 [plasma membrane] (R-HSA-9666643)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.527	2
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.524	4
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.524	2
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.462	2

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