Inhibition of membrane repair

Stable Identifier
R-HSA-9635644
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Inhibition of membrane repair
Click the image above or here to open this pathway in the Pathway Browser
When the phagosomal membrane is injured, this is sensed and acted upon both by the host phagocyte and Mtb. While the host repair system is activated, the bacterium is secreting proteins that block host repair components, effectively inhibiting repair (Mittal et al. 2018).
Literature References
PubMed ID Title Journal Year
30482832 Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response

Uwase, G, Philips, JA, Köster, S, Hanson, PI, Tinaztepe, E, Mittal, E, Mehra, A, Skowyra, ML

MBio 2018
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
modulation by symbiont of host process (0044003)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Pardo, AM  (2019-02-06)
Cite Us!