Eis acetylates DUSP16

Stable Identifier
R-HSA-9636560
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Eis acetylates DUSP16
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Mtb N-acetyltransferase Eis (Eis) acts as an N-acetyltransferase to acetylate lysine at coordinate 55 within the docking domain of the human dual specificity protein phosphatase 16 (DUSP16). This acetylation significantly down-regulates the phosphorylation of c-Jun N-terminal kinase (JNK) (Kim et al. 2012).
Literature References
PubMed ID Title Journal Year
22547814 Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

Lee, JY, Lee, SJ, Suh, SW, Kim, HS, Jo, EK, Song, J, Kim, J, Yoon, HJ, Lee, HM, Kim, DJ, An, DR, Im, HN, Kim, KH, Yoon, JY, Kim, HJ, Kim, KH

Proc. Natl. Acad. Sci. U.S.A. 2012
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Catalyst Activity

N-acetyltransferase activity of Eis [cytosol]

Physical Entity
Eis [cytosol] (Mycobacterium tuberculosis)
Activity
N-acetyltransferase activity (GO:0008080)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Pardo, AM  (2019-02-13)
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