esxA binds B2M

Stable Identifier
R-HSA-9637635
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
esxA binds B2M
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mtb 6 kDa early secretory antigenic target (esxA) binds to freely available human beta-2-microglobulin (B2M) in the endoplasmic reticulum lumen, inhibiting the loading of antigen-derived peptides to B2M, a component of the class I major histocompatibility complex (MHC-I complex) (Sreejit et al. 2014).
Literature References
PubMed ID Title Journal Year
25356553 The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage

Sreejit, G, Parveen, N, Ghosh, S, Mukhopadhyay, S, Jha, V, Valluri, VL, Ahmed, A

PLoS Pathog. 2014
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-19)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Pardo, AM  (2019-02-19)
Cite Us!