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TLR2 [plasma membrane]
Stable Identifier
R-HSA-9637646
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Toll-like receptor 2, TLR2_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P42229 STAT5A
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Modulation by Mtb of host immune system (Homo sapiens)
EsxA binds TLR2 (Homo sapiens)
TLR2 [plasma membrane] (Homo sapiens)
Rv2779c binds TLR2 (Homo sapiens)
TLR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60603 TLR2
Gene Names
TLR2, TIL4
Chain
signal peptide:1-20, chain:21-784
Reference Genes
BioGPS Gene:7097 TLR2
COSMIC (genes):TLR2 TLR2
CTD Gene:7097 TLR2
dbSNP Gene:7097 TLR2
ENSEMBL:ENSG00000137462 TLR2
HGNC:11848 TLR2
KEGG:hsa:7097 TLR2
Monarch:7097 TLR2
NCBI Gene:7097 TLR2
OMIM:603028 TLR2
UCSC:O60603 TLR2
Reference Transcript
RefSeq:XM_011532216.2 TLR2
RefSeq:XM_017008576.1 TLR2
RefSeq:NM_001318791.1 TLR2
RefSeq:NM_001318789.1 TLR2
RefSeq:NM_001318796.1 TLR2
RefSeq:NM_001318793.1 TLR2
RefSeq:NM_003264.4 TLR2
RefSeq:XM_017008574.1 TLR2
RefSeq:XM_017008575.1 TLR2
RefSeq:NM_001318787.1 TLR2
RefSeq:NM_001318790.1 TLR2
RefSeq:XM_017008573.1 TLR2
RefSeq:XM_011532215.2 TLR2
RefSeq:NM_001318795.1 TLR2
Other Identifiers
11736273_a_at
11736274_at
11754833_a_at
16971631
204924_PM_at
204924_at
2748348
2748352
2748353
2748354
2748355
2748356
2748357
2748358
2748372
2748374
2748375
2748376
2748377
2748379
2748389
40310_at
67317_r_at
7097
8097903
A_14_P200129
A_23_P92499
GE54434
GE835871
GO:0001530
GO:0001540
GO:0001666
GO:0001774
GO:0001875
GO:0002224
GO:0002376
GO:0003824
GO:0004888
GO:0005515
GO:0005737
GO:0005794
GO:0005886
GO:0006355
GO:0006691
GO:0006915
GO:0006954
GO:0006955
GO:0007165
GO:0007252
GO:0007612
GO:0008285
GO:0008289
GO:0009636
GO:0009986
GO:0010628
GO:0012501
GO:0014005
GO:0016020
GO:0016787
GO:0030177
GO:0030667
GO:0030670
GO:0031410
GO:0031663
GO:0032289
GO:0032493
GO:0032496
GO:0032570
GO:0032722
GO:0032728
GO:0032733
GO:0032735
GO:0032741
GO:0032755
GO:0032757
GO:0032760
GO:0032868
GO:0034134
GO:0035325
GO:0035354
GO:0035355
GO:0038023
GO:0038124
GO:0038187
GO:0042495
GO:0042496
GO:0042497
GO:0042802
GO:0042834
GO:0042995
GO:0043226
GO:0043235
GO:0044297
GO:0044877
GO:0045087
GO:0045121
GO:0045944
GO:0046209
GO:0048714
GO:0048856
GO:0050729
GO:0050765
GO:0050830
GO:0050877
GO:0051092
GO:0051607
GO:0051770
GO:0051964
GO:0060089
GO:0061809
GO:0070542
GO:0071221
GO:0071223
GO:0071346
GO:0071723
GO:0071726
GO:0071727
GO:0098542
GO:1901224
GO:1903974
GO:1904466
HMNXSV003000262
ILMN_1772387
PH_hs_0030266
TC04000775.hg
TC04002279.hg
g4507528_3p_at
p26819
p33882
p33883
Participates
as a component of
Rv2779c:TLR2 [plasma membrane] (Homo sapiens)
EsxA:TLR2 [plasma membrane] (Homo sapiens)
as an input of
Rv2779c binds TLR2 (Homo sapiens)
EsxA binds TLR2 (Homo sapiens)
Other forms of this molecule
TLR2 [plasma membrane]
TLR2 [secretory granule membrane]
Cross References
RefSeq
NP_001305716.1
,
NP_001305722.1
,
XP_011530517.1
,
XP_011530518.1
,
NP_001305718.1
,
NP_001305719.1
,
XP_016864062.1
,
NP_001305725.1
,
NP_001305724.1
,
NP_001305720.1
,
NP_003255.2
,
XP_016864065.1
,
XP_016864063.1
,
XP_016864064.1
ZINC - World Drugs
TLR2_HUMAN
Guide to Pharmacology - Targets
1752
OpenTargets
ENSG00000137462
ENSEMBL
ENST00000642580
,
ENSP00000496208
,
ENST00000260010
,
ENSP00000493968
,
ENSP00000494425
,
ENSP00000495339
,
ENST00000643501
,
ENST00000646900
,
ENSP00000260010
,
ENST00000646219
,
ENSP00000496676
,
ENST00000642700
ZINC - Substances
TLR2_HUMAN
ZINC - Biogenic
TLR2_HUMAN
ZINC target
O60603
PRO
O60603
PDB
6NIG
,
8AR0
,
2Z7X
,
2Z80
,
1O77
,
1FYX
,
1FYW
ZINC - Metabolites
TLR2_HUMAN
HPA
ENSG00000137462-TLR2
Pharos - Targets
O60603
ZINC - Predictions - Purchasable
TLR2_HUMAN
HMDB Protein
HMDBP12412
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.737
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.681
3
UniProt:Q9Y2C9 TLR6
1
TLR6 [plasma membrane]
(R-HSA-168061)
0.681
5
UniProt:P61073 CXCR4
1
CXCR4 [plasma membrane]
(R-HSA-2980772)
0.59
3
UniProt:O60603 TLR2
3
TLR2 [plasma membrane]
(R-HSA-167992)
TLR2 [secretory granule membrane]
(R-HSA-6804777)
TLR2 [plasma membrane]
(R-HSA-9637646)
0.581
4
UniProt:Q96DA0 PAUF
0.576
3
UniProt:Q9BXR5 TLR10
1
TLR10 [plasma membrane]
(R-HSA-167926)
0.573
3
UniProt:Q6NUQ4 TM214
0.527
2
UniProt:P42229 STAT5A
4
STAT5A [cytosol]
(R-HSA-380747)
p-Y694-STAT5A [cytosol]
(R-HSA-507936)
p-Y694-STAT5A [nucleoplasm]
(R-HSA-507995)
STAT5A [nucleoplasm]
(R-HSA-9701901)
0.527
2
UniProt:P36894 BMPR1A
2
p-4S-BMPR1A [plasma membrane]
(R-HSA-201448)
BMPR1A [plasma membrane]
(R-HSA-201480)
0.527
2
UniProt:Q15399 TLR1
1
TLR1 [plasma membrane]
(R-HSA-6787702)
0.508
3
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