CpnT hydrolyses NAD+

Stable Identifier
R-HSA-9637699
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CpnT hydrolyses NAD+
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The C-terminal domain of CpnT, tuberculosis necrotizing toxin (TNT) has NAD+ hydrolase activity. Its secretion depletes NAD+ in the cytosol of the phagocyte which leads to necrosis (Sun et al. 2015).

Literature References
PubMed ID Title Journal Year
26237511 The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

Cingolani, G, Siroy, A, Sun, J, Doornbos, KS, Speer, A, Lokareddy, RK, Niederweis, M

Nat. Struct. Mol. Biol. 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

NAD glycohydrolase activity of cpnT [cytosol]

Physical Entity
cpnT [cytosol] (Mycobacterium tuberculosis)
Activity
NAD glycohydrolase activity (GO:0061810)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Rhea
Authored
Stephan, R  (2019-02-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Jassal, B  (2019-02-19)
Cite Us!