CpnT hydrolyses NAD+

Stable Identifier
R-HSA-9637699
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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CpnT hydrolyses NAD+
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The C-terminal domain of CpnT, tuberculosis necrotizing toxin (TNT) has NAD+ hydrolase activity. Its secretion depletes NAD+ in the cytosol of the phagocyte which leads to necrosis (Sun et al. 2015).
Literature References
PubMed ID Title Journal Year
26237511 The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

Sun, J, Siroy, A, Lokareddy, RK, Speer, A, Doornbos, KS, Cingolani, G, Niederweis, M

Nat. Struct. Mol. Biol. 2015
Participants
Input
Output
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as an event of
Catalyst Activity

NAD+ nucleosidase activity, cyclic ADP-ribose generating of CpnT [cytosol]

Physical Entity
CpnT [cytosol] (Mycobacterium tuberculosis)
Activity
NAD+ nucleosidase activity, cyclic ADP-ribose generating (GO:0061809)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
RHEA
Mondo
Authored
Stephan, R  (2019-02-06)
Reviewed
Deffur, A  (2019-10-23)
Wilkinson, RJ  (2019-10-23)
Created
Jassal, B  (2019-02-19)
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