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WDR59 [lysosomal membrane]
Stable Identifier
R-HSA-9638236
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
fullName evidence="15"GATOR complex protein WDR59, WDR59_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
GATOR2 [lysosomal membrane] (Homo sapiens)
WDR59 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6PJI9 WDR59
Gene Names
WDR59, KIAA1923, FP977
Chain
chain:1-974
Reference Genes
BioGPS Gene:79726 WDR59
COSMIC (genes):WDR59 WDR59
CTD Gene:79726 WDR59
dbSNP Gene:79726 WDR59
ENSEMBL:ENSG00000103091 WDR59
ENSEMBL_homo_sapiens_GENE:ENSG00000103091.15 WDR59
HGNC:25706 WDR59
KEGG Gene (Homo sapiens):79726 WDR59
Monarch:79726 WDR59
NCBI Gene:79726 WDR59
OMIM:617418 WDR59
UCSC:Q6PJI9 WDR59
Reference Transcript
RefSeq:NM_001324171.1 WDR59
RefSeq:NM_030581.3 WDR59
Other Identifiers
11716487_a_at
11745592_a_at
11754255_a_at
16828367
218505_PM_at
218505_at
219586_PM_at
219586_at
221981_PM_s_at
221981_s_at
3668801
3699182
3699183
3699184
3699185
3699186
3699187
3699188
3699190
3699191
3699193
3699195
3699198
3699200
3699201
3699206
3699208
3699209
3699211
3699212
3699214
3699217
3699222
3699225
3699227
3699230
3699232
3699233
3699234
3699239
3699240
3699241
3699242
3699243
3699248
3699253
3699254
49300_at
55085_at
58965_at
58967_g_at
79726
8002802
A_23_P206856
GE572472
GE61819
GO:0005515
GO:0005764
GO:0005765
GO:0005773
GO:0005774
GO:0005829
GO:0016020
GO:0023052
GO:0031669
GO:0032008
GO:0034198
GO:0035591
GO:0035859
GO:0043226
GO:0043231
GO:0046872
GO:0060090
GO:0061700
GO:1904262
GO:1904263
HMNXSV003014805
HMNXSV003033903
Hs.180058.1.S1_3p_a_at
ILMN_1795428
PH_hs_0024946
TC16001272.hg
g13375935_3p_at
g13386493_3p_at
Participates
as a component of
GATOR2 [lysosomal membrane] (Homo sapiens)
Inferred To
wdr59 [lysosomal membrane]
(Xenopus tropicalis)
Wdr59 [lysosomal membrane]
(Rattus norvegicus)
WDR59 [lysosomal membrane]
(Bos taurus)
WDR59 [lysosomal membrane]
(Canis familiaris)
WDR59 [lysosomal membrane]
(Dictyostelium discoideum)
WDR59 [lysosomal membrane]
(Gallus gallus)
WDR59 [lysosomal membrane]
(Mus musculus)
WDR59 [lysosomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001311100.1
,
NP_085058.3
OpenTargets
ENSG00000103091
GeneCards
Q6PJI9
HPA
ENSG00000103091-WDR59
Ensembl
ENSG00000103091
,
ENSP00000482446
,
ENST00000616369
,
ENST00000262144
,
ENSP00000262144
PRO
Q6PJI9
Pharos - Targets
Q6PJI9
PDB
7UHY
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55735 SEC13
4
SEC13 [lysosomal membrane]
(R-HSA-9638246)
SEC13 [endoplasmic reticulum membrane]
(R-HSA-203994)
SEC13 [cytosol]
(R-HSA-203981)
SEC13 [ER to Golgi transport vesicle membrane]
(R-HSA-204012)
0.527
2
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