Ca2+ binds KCNIP3

Stable Identifier
R-HSA-9640063
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Ca2+ binds KCNIP3
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Upon neuronal activity-induced influx of calcium ions, Ca2+ binds to KCNIP3 homotetramers. Calcium-bound KCNIP3 cannot associate with target DNA sequences (Carrion et al. 1999). Based on studies with mouse Kcnip3, which has amino acid sequence 91% identical to human KCNIP3, Ca2+ binds to two high-affinity sites in Kcnip3 under physiological conditions, when magnesium is present. In the absence of magnesium, Ca2+ can bind to three sites in KCNIP3 (Osawa et al. 2005).
Literature References
PubMed ID Title Journal Year
10078534 DREAM is a Ca2+-regulated transcriptional repressor

Link, WA, Naranjo, JR, Carrión, AM, Mellström, B, Ledo, F

Nature 1999
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Ca2+ binds Kcnip3 (Mus musculus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-03-20)
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