Reactome | E2 enzyme UBE2N:UBE2V1 binds ubiquitin

E2 enzyme UBE2N:UBE2V1 binds ubiquitin

Stable Identifier

R-HSA-9640480

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ubiquitination is the covalent attachment of ubiquitin molecules to substrate proteins with three enzymatic steps - E1 ubiquitin activation, E2 ubiquitin conjugation and E3 ubiquitin protein ligase. UBE2V1 and UBE2N are E2 ubiquitin-conjugating enzymes that form a complex and bind ubiquitin molecules at K63. This leads to the additional binding of ubiquitin entities and formation of a polyubiquitin chain (Hofmann RM et al. 1999). Experiments confirming this finding were performed in yeast cells.

Literature References

PubMed ID	Title	Journal	Year
10089880	Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair Pickart, CM, Hofmann, RM	Cell	1999