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Misfolded PARK7 [cytosol]
Stable Identifier
R-HSA-9641100
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
L166P PARK7, Misfolded DJ-1
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Aggrephagy (Homo sapiens)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Homo sapiens)
Misfolded Proteins [cytosol] (Homo sapiens)
Misfolded PARK7 [cytosol] (Homo sapiens)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Homo sapiens)
Misfolded Proteins [cytosol] (Homo sapiens)
Misfolded PARK7 [cytosol] (Homo sapiens)
Parkin transfers Ub to misfolded proteins (Homo sapiens)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Homo sapiens)
Misfolded Proteins [cytosol] (Homo sapiens)
Misfolded PARK7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99497 PARK7
Gene Names
PARK7
Chain
initiator methionine:, chain:2-, propeptide:-189
Reference Genes
BioGPS Gene:11315 PARK7
COSMIC (genes):PARK7 PARK7
CTD Gene:11315 PARK7
dbSNP Gene:11315 PARK7
ENSEMBL:ENSG00000116288 PARK7
HGNC:16369 PARK7
KEGG:hsa:11315 PARK7
Monarch:11315 PARK7
NCBI Gene:11315 PARK7
OMIM:602533 PARK7
UCSC:Q99497 PARK7
Reference Transcript
RefSeq:NM_001123377.1 PARK7
RefSeq:NM_007262.4 PARK7
RefSeq:XM_005263424.3 PARK7
Other Identifiers
11315
11742986_at
16653207
16653209
16653235
16658568
18670534
18670535
18670536
18670537
18670538
18670539
18670540
18670541
18670542
18670543
18670544
18670545
18670546
200006_PM_at
200006_at
2318737
2318738
2318739
2318740
2318741
2318743
2318744
2318745
2318746
2318747
2318748
2318749
2318751
2318753
2318754
2318755
2318756
2318757
2318775
2318815
2318817
2318819
2318871
38974_at
7893469
7893514
7893721
7893831
7893952
7894579
7895627
7895911
7896108
7896422
7896468
7897404
A_23_P74740
A_33_P3231981
D61380_at
GE81739
GO:0000785
GO:0001933
GO:0001963
GO:0002866
GO:0003713
GO:0003723
GO:0003729
GO:0003824
GO:0005102
GO:0005507
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005758
GO:0005759
GO:0005783
GO:0005829
GO:0005886
GO:0005912
GO:0006281
GO:0006355
GO:0006508
GO:0006914
GO:0006954
GO:0006979
GO:0007005
GO:0007265
GO:0007338
GO:0008021
GO:0008047
GO:0008233
GO:0008344
GO:0009438
GO:0010273
GO:0010628
GO:0010629
GO:0016020
GO:0016209
GO:0016491
GO:0016532
GO:0016605
GO:0016684
GO:0016787
GO:0016829
GO:0019249
GO:0019430
GO:0019826
GO:0019899
GO:0019900
GO:0019955
GO:0022414
GO:0023052
GO:0030073
GO:0030091
GO:0030414
GO:0030424
GO:0030521
GO:0030546
GO:0031334
GO:0031397
GO:0031410
GO:0032435
GO:0032757
GO:0033138
GO:0033234
GO:0034599
GO:0034614
GO:0036470
GO:0036471
GO:0036478
GO:0036524
GO:0042177
GO:0042542
GO:0042593
GO:0042743
GO:0042802
GO:0042803
GO:0043005
GO:0043226
GO:0043523
GO:0043524
GO:0044297
GO:0044388
GO:0044390
GO:0045121
GO:0045202
GO:0045296
GO:0045340
GO:0045944
GO:0046295
GO:0046826
GO:0048471
GO:0050681
GO:0050727
GO:0050787
GO:0050821
GO:0051583
GO:0051881
GO:0051897
GO:0051899
GO:0051920
GO:0055086
GO:0055105
GO:0060081
GO:0060090
GO:0060765
GO:0061691
GO:0061727
GO:0070062
GO:0070301
GO:0070994
GO:0097110
GO:0098754
GO:0098772
GO:0098793
GO:0098869
GO:0106044
GO:0106045
GO:0106046
GO:0110095
GO:0140041
GO:0140096
GO:0140104
GO:0140110
GO:0140297
GO:0140299
GO:1900182
GO:1900242
GO:1901984
GO:1902176
GO:1902177
GO:1902236
GO:1902903
GO:1902958
GO:1903073
GO:1903094
GO:1903122
GO:1903135
GO:1903136
GO:1903181
GO:1903189
GO:1903190
GO:1903197
GO:1903376
GO:1903377
GO:1903384
GO:1903427
GO:1903428
GO:1903599
GO:1903751
GO:1905259
GO:1990381
GO:1990422
GO:2000379
GO:2001237
HMNXSV003049397
ILMN_1744713
PH_hs_0025114
TC01000101.hg
TC09000477.hg
g6005748_3p_at
p33735
Participates
as a member of
Misfolded Proteins [cytosol] (Homo sapiens)
Other forms of this molecule
PolyUb-Misfolded PARK7 [lysosomal lumen]
PolyUb-Misfolded PARK7 [cytosol]
Ub-Misfolded PARK7 [cytosol]
PolyUb-Misfolded PARK7 [late endosome lumen]
PARK7 [nucleoplasm]
monoSUMO1-K130-PARK7 [nucleoplasm]
Inferred To
hsp3106 [cytosol]
(Schizosaccharomyces pombe)
dj-1beta [cytosol]
(Drosophila melanogaster)
Park7 [cytosol]
(Mus musculus)
Park7 [cytosol]
(Rattus norvegicus)
PARK7 [cytosol]
(Bos taurus)
PARK7 [cytosol]
(Canis familiaris)
PARK7 [cytosol]
(Sus scrofa)
DJ-1 [cytosol]
(Gallus gallus)
Misfolded PARK7 [cytosol]
(Plasmodium falciparum)
djr-1.1 [cytosol]
(Caenorhabditis elegans)
park7 [cytosol]
(Danio rerio)
park7 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
L-leucine 166 replaced with L-proline
Coordinate
166
PsiMod
L-leucine removal [MOD:01641]
A protein modification that effectively removes or replaces an L-leucine.
L-proline residue [MOD:00024]
A protein modification that effectively converts a source amino acid residue to L-proline.
Cross References
RefSeq
NP_009193.2
,
XP_005263481.1
,
NP_001116849.1
OpenTargets
ENSG00000116288
ENSEMBL
ENST00000493678
,
ENST00000377491
,
ENST00000338639
,
ENSP00000366708
,
ENSP00000465404
,
ENSP00000340278
,
ENSP00000366711
,
ENST00000377488
,
ENST00000493373
,
ENSP00000418770
HPA
ENSG00000116288-PARK7
PRO
Q99497
Pharos - Targets
Q99497
GlyGen
Q99497
Orphanet
PARK7
PDB
3SF8
,
5SY6
,
2RK3
,
2RK6
,
1PDW
,
6AF5
,
4ZGG
,
4S0Z
,
3B36
,
5IP5
,
6AF9
,
4RKY
,
6AFH
,
4P36
,
6E5Z
,
6AFA
,
6AFB
,
6AFJ
,
1Q2U
,
1UCF
,
7C62
,
4OQ4
,
6M8Z
,
1P5F
,
1J42
,
3CY6
,
3CYF
,
6AFC
,
6AFD
,
4P35
,
6AFF
,
3B38
,
3B3A
,
3CZA
,
4MNT
,
2RK4
,
4OGF
,
6AF7
,
4N12
,
5SY9
,
1PDV
,
4RKW
,
1SOA
,
4N0M
,
2OR3
,
3F71
,
1PE0
,
6AFG
,
5SYA
,
4BTE
,
6AFI
,
2R1T
,
2R1V
,
2R1U
,
4MTC
,
4P2G
,
3BWE
,
7PA3
,
6AFE
,
7PA2
,
6AFL
,
4P34
,
8PQ0
,
3CZ9
,
8PPW
,
3EZG
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.714
6
UniProt:Q99497 PARK7
7
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
PARK7 [nucleoplasm]
(R-HSA-3900141)
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
0.692
3
UniProt:Q8NFJ9 BBS1
1
BBS1 [cytosol]
(R-HSA-5617640)
0.666
4
UniProt:Q96FW1 OTUB1
2
OTUB1 [nucleoplasm]
(R-HSA-6783242)
OTUB1 [cytosol]
(R-HSA-933411)
0.666
4
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.653
9
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
16
UniProt:P32322 PYCR1
1
PYCR1 [mitochondrial matrix]
(R-HSA-70656)
0.61
5
UniProt:P10275 AR
4
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
0.602
6
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.576
4
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.576
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:Q9BYQ4 KRTAP9-2
1
KRTAP9-2 [cytosol]
(R-HSA-6809965)
0.556
3
UniProt:P06241-3 FYN
0.556
3
UniProt:Q8IUW3 SPA2L
0.556
3
UniProt:Q9GZS3 SKIC8
2
WDR61 [cytosol]
(R-HSA-8931534)
WDR61 [nucleoplasm]
(R-HSA-8866696)
0.556
3
UniProt:Q8N5S9-2 Q8N5S92
0.556
3
UniProt:Q8NFH3 NUP43
2
NUP43 [nuclear envelope]
(R-HSA-157739)
NUP43 [cytosol]
(R-HSA-376243)
0.556
3
UniProt:Q9ULX5 RN112
0.556
3
UniProt:Q6DN90-2 Q6DN902
0.556
3
UniProt:Q9HD26 GOPC
3
GOPC [lysosomal membrane]
(R-HSA-5627281)
GOPC [plasma membrane]
(R-HSA-5626572)
GOPC [Golgi-associated vesicle membrane]
(R-HSA-5627067)
0.556
3
IntAct:EBI-25849442 CCSB
0.556
3
UniProt:P01023 A2M
2
A2M [extracellular region]
(R-HSA-49291)
A2M [platelet alpha granule lumen]
(R-HSA-139834)
0.556
3
UniProt:P63010-2 AP2B1
0.556
3
UniProt:Q6ZNA4-2 Q6ZNA42
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:O14656-2 TOR1A
0.556
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.537
4
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.527
2
UniProt:Q6GQQ9 OTUD7B
1
OTUD7B [cytosol]
(R-HSA-5212662)
0.524
3
UniProt:P31483 TIA1
1
TIA1 [nucleoplasm]
(R-HSA-6803498)
0.463
3
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