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PolyUb-Misfolded Proteins [cytosol]
Stable Identifier
R-HSA-9641120
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Chaperone Mediated Autophagy (Homo sapiens)
GFAP binds LAMP2a multimer (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)
HSPA8:Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
HSPA8:Substrate binds LAMP2a (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
HSPA8:Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Substrate:LAMP2a binds HSP90 (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)
HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Late endosomal microautophagy (Homo sapiens)
HSPA8 binds substrate (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
HSPA8:substrate binds late endosomal phospholipids (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PL:HSPA8:Autophagy substrate [late endosome membrane] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Substrate translocates into late endosomal lumen (Homo sapiens)
PL:HSPA8:Autophagy substrate [late endosome membrane] (Homo sapiens)
HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Aggrephagy (Homo sapiens)
Aggresome dissociates from dynein and microtubule (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Dynein motors transport misfolded proteins (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Misfolded proteins:HDAC6:Dynein motor binds microtubule (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
VCP:PolyUb-Misfolded Proteins:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Homo sapiens)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [microtubule organizing center] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
VCP:PolyUb-Misfolded Proteins:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins [cytosol] (Homo sapiens)
Participants
members
PolyUb-Misfolded cilia proteins [cytosol]
(Homo sapiens)
PolyUb-misfolded nascent CFTR [cytosol]
(Homo sapiens)
PolyUb-Misfolded PARK7 [cytosol]
(Homo sapiens)
Participates
as an output of
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)
as a component of
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
VCP:PolyUb-Misfolded Proteins:HDAC6:HSP90:HSF1 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
as an input of
PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)
Inferred To
PolyUb-Misfolded Proteins [cytosol]
(Bos taurus)
PolyUb-Misfolded Proteins [cytosol]
(Caenorhabditis elegans)
PolyUb-Misfolded Proteins [cytosol]
(Canis familiaris)
PolyUb-Misfolded Proteins [cytosol]
(Danio rerio)
PolyUb-Misfolded Proteins [cytosol]
(Dictyostelium discoideum)
PolyUb-Misfolded Proteins [cytosol]
(Drosophila melanogaster)
PolyUb-Misfolded Proteins [cytosol]
(Gallus gallus)
PolyUb-Misfolded Proteins [cytosol]
(Mus musculus)
PolyUb-Misfolded Proteins [cytosol]
(Plasmodium falciparum)
PolyUb-Misfolded Proteins [cytosol]
(Rattus norvegicus)
PolyUb-Misfolded Proteins [cytosol]
(Sus scrofa)
PolyUb-Misfolded Proteins [cytosol]
(Xenopus tropicalis)
hsp3106 [cytosol]
(Schizosaccharomyces pombe)
Ghost homologue of PolyUb-Misfolded Proteins [cytosol]
(Saccharomyces cerevisiae)
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