p-S54-PDE4B hydrolyses cAMP

Stable Identifier
R-HSA-9644869
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cAMP hydrolysis by PDE4B
ReviewStatus
5/5
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p-S54-PDE4B hydrolyses cAMP
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B) hydrolyzes cAMP to AMP (Huston et al. 1997). Phosphorylation of serine 54 on PDE4B increases its activity.
Literature References
PubMed ID Title Journal Year
9371714 Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

Steele, MR, Huston, E, Bolger, GB, Perry, MJ, Russell, A, Owens, RJ, Ross, AH, Lumb, S, Houslay, MD, Catterall, C

Biochem J 1997
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Catalyst Activity

3',5'-cyclic-AMP phosphodiesterase activity of p-S54-PDE4B-3 [cytosol]

Physical Entity
p-S54-PDE4B-3 [cytosol] (Homo sapiens)
Activity
3',5'-cyclic-AMP phosphodiesterase activity (GO:0004115)
Orthologous Events
p-S54-PDE4B hydrolyses cAMP (Bos taurus)
p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)
p-S54-PDE4B hydrolyses cAMP (Canis familiaris)
p-S54-PDE4B hydrolyses cAMP (Dictyostelium discoideum)
p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)
p-S54-PDE4B hydrolyses cAMP (Gallus gallus)
p-S54-PDE4B hydrolyses cAMP (Mus musculus)
p-S54-PDE4B hydrolyses cAMP (Plasmodium falciparum)
p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)
p-S54-PDE4B hydrolyses cAMP (Sus scrofa)
p-S54-PDE4B hydrolyses cAMP (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2019-04-26)
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