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Aggrephagy
Stable Identifier
R-HSA-9646399
DOI
10.3180/R-HSA-9646399.1
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
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Aggrephagy (Homo sapiens)
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When the capacity of the proteosome to degrade misfolded proteins is limited, the alternate route to eliminate denatured proteins is via forming aggresomes - a process known as aggrephagy. Aggresome formation starts with ubiquitination of misfolded proteins following transport to the microtubule-organizing center (MTOC) with the help of dynein motor proteins. At the MTOC the cargo is encapsulated with intermediate filament proteins to result in the aggresome. Subsequently, this aggresome recruits chaperones that result in its autophagic elimination (Garcia Mata R et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
12010457
Hassles with taking out the garbage: aggravating aggresomes
Gao, YS
,
Sztul, E
,
Garcia-Mata, R
Traffic
2002
Participants
Events
ROS positively regulates misfolding of cilia proteins
(Homo sapiens)
Misfolded proteins translocate from cilium to cytosol
(Homo sapiens)
E2 enzyme UBE2N:UBE2V1 binds ubiquitin
(Homo sapiens)
Parkin binds Ub:UBE2N:UBE2V1
(Homo sapiens)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub
(Homo sapiens)
Parkin transfers Ub to misfolded proteins
(Homo sapiens)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
(Homo sapiens)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
(Homo sapiens)
PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
(Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
(Homo sapiens)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
(Homo sapiens)
Misfolded proteins:HDAC6:Dynein motor binds microtubule
(Homo sapiens)
Dynein motors transport misfolded proteins
(Homo sapiens)
PolyUb-Misfolded proteins bind vimentin to form aggresome
(Homo sapiens)
Aggresome dissociates from dynein and microtubule
(Homo sapiens)
Participates
as an event of
Selective autophagy (Homo sapiens)
Event Information
Go Biological Process
aggrephagy (0035973)
Orthologous Events
Aggrephagy (Bos taurus)
Aggrephagy (Caenorhabditis elegans)
Aggrephagy (Canis familiaris)
Aggrephagy (Danio rerio)
Aggrephagy (Dictyostelium discoideum)
Aggrephagy (Drosophila melanogaster)
Aggrephagy (Gallus gallus)
Aggrephagy (Mus musculus)
Aggrephagy (Plasmodium falciparum)
Aggrephagy (Rattus norvegicus)
Aggrephagy (Saccharomyces cerevisiae)
Aggrephagy (Schizosaccharomyces pombe)
Aggrephagy (Sus scrofa)
Aggrephagy (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000293
,
BIOMD0000000220
,
BIOMD0000000575
,
BIOMD0000000634
Authored
Varusai, TM (2019-05-23)
Reviewed
Metzakopian, E (2019-05-24)
Created
Varusai, TM (2019-05-23)
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