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ERBB2 L755M [plasma membrane]
Stable Identifier
R-HSA-9646517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
HER2 L755M, ERBB2 Leu755Met, HER2 Leu755Met
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 KD Mutants (Homo sapiens)
ERBB2 KD mutants bind TKIs (Homo sapiens)
ERBB2 KD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (TKI sensitive) [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (afatinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (lapatinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (neratinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (osimertinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (sapitinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:TKIs [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:afatinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (afatinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:lapatinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (lapatinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:neratinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (neratinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:osimertinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (osimertinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:sapitinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (sapitinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants bind trastuzumab (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (trastuzumab) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (trastuzumab) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants heterodimerize (Homo sapiens)
ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (trastuzumab sensitive):trastuzumab [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (trastuzumab) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:TKIs [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:afatinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (afatinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:lapatinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (lapatinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:neratinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (neratinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:osimertinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (osimertinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:sapitinib [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (sapitinib) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] (Homo sapiens)
ERBB2 L755M [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04626 ERBB2
Gene Names
ERBB2, HER2, MLN19, NEU, NGL
Chain
signal peptide:1-22, chain:23-1255
Reference Genes
BioGPS Gene:2064 ERBB2
COSMIC (genes):ERBB2 ERBB2
CTD Gene:2064 ERBB2
dbSNP Gene:2064 ERBB2
ENSEMBL:ENSG00000141736 ERBB2
ENSEMBL_homo_sapiens_GENE:ENSG00000141736.14 ERBB2
HGNC:3430 ERBB2
KEGG Gene (Homo sapiens):2064 ERBB2
Monarch:2064 ERBB2
NCBI Gene:2064 ERBB2
OMIM:164870 ERBB2
UCSC:P04626 ERBB2
Reference Transcript
RefSeq:NM_001289936.1 ERBB2
RefSeq:NM_001289938.1 ERBB2
RefSeq:NM_001005862.2 ERBB2
RefSeq:NM_004448.3 ERBB2
Other Identifiers
11736472_a_at
11750611_a_at
11751416_a_at
11755005_a_at
11762165_x_at
16833839
1802_s_at
1901_s_at
2064
210930_3p_s_at
210930_PM_s_at
210930_s_at
216836_PM_s_at
216836_s_at
33218_at
3720403
3720404
3720405
3720406
3720407
3720408
3720410
3720411
3720412
3720413
3720417
3720420
3720422
3720423
3720425
3720427
3720428
3720431
3720432
3720433
3720434
3720436
3720438
3720440
3720442
3720444
3720446
3720447
3720449
3720452
3720454
3720455
3720457
3720458
3720460
3720461
3720462
3720463
3720464
3720465
3720466
3720467
3720468
3720469
3720470
3720471
8006906
A_14_P101724
A_14_P126019
A_23_P89249
A_24_P284420
A_33_P3292596
GE57810
GO:0000166
GO:0001042
GO:0001934
GO:0002116
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0004888
GO:0005102
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0007155
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008045
GO:0008284
GO:0009925
GO:0010008
GO:0010628
GO:0012501
GO:0014044
GO:0015026
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019838
GO:0022008
GO:0023052
GO:0030154
GO:0030182
GO:0030307
GO:0030971
GO:0031410
GO:0031594
GO:0032587
GO:0032886
GO:0033080
GO:0033088
GO:0034330
GO:0035025
GO:0035556
GO:0036211
GO:0038127
GO:0038133
GO:0038134
GO:0038135
GO:0038143
GO:0042060
GO:0042127
GO:0042552
GO:0042734
GO:0042802
GO:0042995
GO:0043066
GO:0043125
GO:0043209
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043491
GO:0045727
GO:0045765
GO:0045785
GO:0045943
GO:0046982
GO:0048471
GO:0048709
GO:0048856
GO:0050679
GO:0060089
GO:0070372
GO:0071363
GO:0071364
GO:0071526
GO:0090314
GO:0098590
GO:0099645
GO:0140096
HMNXSV003015366
HMNXSV003026104
HMNXSV003035749
Hs.323910.2.A1_3p_a_at
ILMN_1717902
ILMN_1728761
ILMN_2352131
PH_hs_0021933
TC17000480.hg
X03363_s_at
g10181232_3p_a_at
Participates
as a candidate of
ERBB2 KD mutants [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (lapatinib) [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (sapitinib) [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] (Homo sapiens)
as a member of
ERBB2 KD mutants (trastuzumab) [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (neratinib) [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (afatinib) [plasma membrane] (Homo sapiens)
ERBB2 KD mutants (osimertinib) [plasma membrane] (Homo sapiens)
Other forms of this molecule
ERBB2 G309E [plasma membrane]
ERBB2 G309A [plasma membrane]
ERBB2 S310F [plasma membrane]
ERBB2 S310Y [plasma membrane]
p-6Y-ERBB2 G309A [plasma membrane]
p-6Y-ERBB2 G309E [plasma membrane]
p-6Y-ERBB2 S310F [plasma membrane]
p-6Y-ERBB2 S310Y [plasma membrane]
p-Y-ERBB2 L755P [plasma membrane]
p-Y-ERBB2 I767M [plasma membrane]
p-Y-ERBB2 T798I [plasma membrane]
p-Y-ERBB2 Y772_A775dup [plasma membrane]
p-Y-ERBB2 T862A [plasma membrane]
p-Y-ERBB2 T798M [plasma membrane]
p-Y-ERBB2 H878Y [plasma membrane]
p-Y-ERBB2 V777L [plasma membrane]
p-Y-ERBB2 L755S [plasma membrane]
p-Y-ERBB2 V777E [plasma membrane]
p-Y-ERBB2 V777M [plasma membrane]
p-Y-ERBB2 L755M [plasma membrane]
p-Y-ERBB2 L755W [plasma membrane]
p-Y-ERBB2 T733I [plasma membrane]
p-Y-ERBB2 H878R [plasma membrane]
p-Y-ERBB2 L869R [plasma membrane]
p-Y-ERBB2 G776S [plasma membrane]
p-Y-ERBB2 L869Q [plasma membrane]
p-Y-ERBB2 G776L [plasma membrane]
p-Y-ERBB2 G776V [plasma membrane]
p-Y-ERBB2 G776C [plasma membrane]
ERBB2 D769Y [plasma membrane]
ERBB2 L755P [plasma membrane]
ERBB2 V842I [plasma membrane]
ERBB2 H878Y [plasma membrane]
ERBB2 T798M [plasma membrane]
ERBB2 D769H [plasma membrane]
ERBB2 T862A [plasma membrane]
ERBB2 Y772_A775dup [plasma membrane]
ERBB2 L755S [plasma membrane]
ERBB2 I767M [plasma membrane]
ERBB2 V777L [plasma membrane]
ERBB2 D769N [plasma membrane]
ERBB2 T733I [plasma membrane]
ERBB2 V777M [plasma membrane]
ERBB2 V777E [plasma membrane]
ERBB2 L755W [plasma membrane]
ERBB2 H878R [plasma membrane]
ERBB2 V842E [plasma membrane]
ERBB2 T798I [plasma membrane]
ERBB2 R896C [plasma membrane]
ERBB2 G778_P780dup [plasma membrane]
ERBB2 R896H [plasma membrane]
ERBB2 G776S [plasma membrane]
ERBB2 L869R [plasma membrane]
ERBB2 L869Q [plasma membrane]
ERBB2 G776C [plasma membrane]
ERBB2 G776L [plasma membrane]
ERBB2 G776V [plasma membrane]
p-6Y-ERBB2 Y772_A775dup [plasma membrane]
p-6Y-ERBB2 V777L [plasma membrane]
p-6Y-ERBB2 H878Y [plasma membrane]
ERBB2 L755_T759del [plasma membrane]
p-6Y-ERBB2 R896C [plasma membrane]
p-6Y-ERBB2 V842I [plasma membrane]
p-6Y-ERBB2 I767M [plasma membrane]
p-6Y-ERBB2 T862A [plasma membrane]
p-6Y-ERBB2 D769H [plasma membrane]
p-6Y-ERBB2 T798I [plasma membrane]
p-6Y-ERBB2 L755P [plasma membrane]
p-6Y-ERBB2 G778_P780dup [plasma membrane]
p-6Y-ERBB2 L755S [plasma membrane]
p-6Y-ERBB2 T798M [plasma membrane]
p-6Y-ERBB2 D769Y [plasma membrane]
p-6Y-ERBB2 V777E [plasma membrane]
p-6Y-ERBB2 T733I [plasma membrane]
p-6Y-ERBB2 L755M [plasma membrane]
p-6Y-ERBB2 V777M [plasma membrane]
p-6Y-ERBB2 V842E [plasma membrane]
p-6Y-ERBB2 D769N [plasma membrane]
p-6Y-ERBB2 R896H [plasma membrane]
p-6Y-ERBB2 L755W [plasma membrane]
p-6Y-ERBB2 H878R [plasma membrane]
p-6Y-ERBB2 E693K [plasma membrane]
p-6Y-ERBB2 R677L [plasma membrane]
p-6Y-ERBB2 Q709L [plasma membrane]
p-6Y-ERBB2 G660D [plasma membrane]
p-6Y-ERBB2 G660R [plasma membrane]
p-6Y-ERBB2 V659K [plasma membrane]
p-6Y-ERBB2 V659E [plasma membrane]
ERBB2 R678Q [plasma membrane]
ERBB2 S653C [plasma membrane]
ERBB2 R677L [plasma membrane]
ERBB2 G660R [plasma membrane]
ERBB2 V659E [plasma membrane]
ERBB2 G660D [plasma membrane]
ERBB2 V659K [plasma membrane]
ERBB2 Q709L [plasma membrane]
ERBB2 E693K [plasma membrane]
p-6Y-ERBB2 R678Q [plasma membrane]
p-6Y-ERBB2 S653C [plasma membrane]
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
ERBB2 [plasma membrane]
p-Y877-ERBB2 [plasma membrane]
p-Y-ERBB2 [plasma membrane]
p-Y,Y877-ERBB2 [plasma membrane]
p-6Y-ERBB2 [plasma membrane]
p-7Y-ERBB2 [plasma membrane]
p-6Y,Y1112-ERBB2 [plasma membrane]
p-7Y,Y1112-ERBB2 [plasma membrane]
Modified Residues
Name
L-leucine 755 replaced with L-methionine
Coordinate
755
PsiMod
L-methionine residue [MOD:00022]
A protein modification that effectively converts a source amino acid residue to L-methionine.
L-leucine removal [MOD:01641]
A protein modification that effectively removes or replaces an L-leucine.
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
skin melanoma
DOID:8923
malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
breast cancer
DOID:1612
malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer
DOID:5672
malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Cross References
RefSeq
NP_001005862.1
,
NP_001276865.1
,
NP_001276867.1
,
NP_004439.2
ZINC - World Drugs
ERBB2_HUMAN
Guide to Pharmacology - Targets
2019
OpenTargets
ENSG00000141736
ZINC - FDA approved
ERBB2_HUMAN
ZINC - Substances
ERBB2_HUMAN
ZINC - Biogenic
ERBB2_HUMAN
ZINC target
P04626
PRO
P04626
PDB
4HRM
,
7MN5
,
4HRL
,
7JXH
,
7MN6
,
2L4K
,
8FFJ
,
7MN8
,
5TQS
,
2N2A
,
3H3B
,
1MFL
,
2A91
,
2JWA
,
7QVK
,
1S78
,
6BGT
,
8JYR
,
4NND
,
6LBX
,
4HRN
,
3MZW
,
3WSQ
,
1N8Z
,
8Q6J
,
3BE1
,
3RCD
,
8U4K
,
5MY6
,
3PP0
,
5OB4
,
8U4L
,
7PCD
,
3WLW
,
6ATT
,
1MFG
,
1MW4
,
6OGE
,
5O4G
,
5K33
,
2KS1
,
1QR1
,
3N85
,
8PWH
,
6J71
,
4GFU
,
8HGO
,
5KWG
,
8HGP
ZINC - Investigational
ERBB2_HUMAN
ZINC - Metabolites
ERBB2_HUMAN
COSMIC
COSV54062219
GeneCards
P04626
HPA
ENSG00000141736-ERBB2
Ensembl
ENSP00000269571
,
ENSP00000385185
,
ENST00000269571
,
ENST00000541774
,
ENST00000406381
,
ENSP00000446466
,
ENSG00000141736
,
ENST00000584601
,
ENSP00000462438
Pharos - Targets
P04626
ZINC - Predictions - Purchasable
ERBB2_HUMAN
HMDB Protein
HMDBP01473
Interactors (73)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21860 ERBB3
0.973
30
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.954
25
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.926
12
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.916
8
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.856
6
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.821
16
UniProt:Q15303 ERBB4
0.816
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.793
5
UniProt:Q14451 GRB7
1
GRB7 [cytosol]
(R-HSA-204819)
0.779
5
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.775
9
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.759
12
UniProt:Q96JA1 LRIG1
2
Ub-LRIG1 [plasma membrane]
(R-HSA-8875434)
LRIG1 [plasma membrane]
(R-HSA-197745)
0.748
7
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.708
11
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.702
8
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.695
5
UniProt:O95292 VAPB
2
VAPB [endoplasmic reticulum membrane]
(R-HSA-429718)
VAPB [Golgi membrane]
(R-HSA-9715115)
0.671
4
UniProt:P02786 TFRC
5
TFRC(1-760) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869124)
TFRC(1-760) [Golgi membrane]
(R-HSA-434330)
TFRC(1-760) [cytoplasmic vesicle membrane]
(R-HSA-434196)
TFRC(1-760) [plasma membrane]
(R-HSA-917983)
TFRC(1-760) [endosome membrane]
(R-HSA-8961829)
0.671
4
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.659
3
UniProt:Q9UJM3 ERRFI
0.659
4
UniProt:P05023 ATP1A1
1
ATP1A1 [plasma membrane]
(R-HSA-936850)
0.643
3
UniProt:P0DTD8 NS7B
0.643
3
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
0.628
4
UniProt:P98172 EFNB1
2
p-Y324,Y329,Y343-EFNB1 [plasma membrane]
(R-HSA-3928412)
EFNB1 [plasma membrane]
(R-HSA-2682327)
0.602
12
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.602
5
UniProt:hspa1a_hspa1b_human-1 EBI-11820565
0.594
3
UniProt:Q9UQF2 JIP1
0.592
4
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.592
8
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.592
3
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.592
4
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.59
10
UniProt:P42679 MATK
1
MATK [cytosol]
(R-HSA-1433581)
0.59
2
IntAct:EBI-4399559 UBIQ
0.589
2
UniProt:Q9HB71 CYBP
0.573
2
UniProt:P31948 STIP1
1
STIP1 [cytosol]
(R-HSA-443857)
0.573
2
UniProt:P16885 PLCG2
8
p-PLCG2 [plasma membrane]
(R-HSA-114602)
PLCG2 [plasma membrane]
(R-HSA-114601)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
(R-HSA-984816)
PLCG2 [cytosol]
(R-HSA-984806)
p-4Y-PLCG2 [plasma membrane]
(R-HSA-2685601)
p-Y753,Y759-PLCG2 [cytosol]
(R-HSA-5607631)
p-Y753,Y759-PLCG2 [plasma membrane]
(R-HSA-5607640)
p-Y-PLCG2 [cytosol]
(R-HSA-9029105)
0.571
3
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.571
3
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.571
2
UniProt:O60884 DNAJA2
1
DNAJA2 [cytosol]
(R-HSA-3371555)
0.569
3
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.569
3
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.567
16
UniProt:Q15075 EEA1
1
EEA1 [endosome membrane]
(R-HSA-187893)
0.567
5
UniProt:Q14974 KPNB1
5
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
0.567
14
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.564
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.558
2
UniProt:Q99952 PTPN18
2
PTPN18 [nucleoplasm]
(R-HSA-9008900)
PTPN18 [cytosol]
(R-HSA-8864101)
0.558
6
UniProt:O95980 RECK
2
cleaved GPI-RECK [extracellular region]
(R-HSA-8941046)
GPI-RECK [plasma membrane]
(R-HSA-8940687)
0.556
4
UniProt:O75367 H2AY
0.556
6
UniProt:Q9P2T1 GMPR2
1
GMPR2 [cytosol]
(R-HSA-514631)
0.553
2
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.553
2
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.553
2
UniProt:Q9P0L0 VAPA
4
VAPA [endoplasmic reticulum membrane]
(R-HSA-429677)
VAPA [azurophil granule membrane]
(R-HSA-6799364)
VAPA [plasma membrane]
(R-HSA-6806269)
VAPA [cytosol]
(R-HSA-9609920)
0.547
2
UniProt:Q14318 FKBP8
2
PolyUb-FKBP8 [mitochondrial outer membrane]
(R-HSA-6783001)
FKBP8 [mitochondrial outer membrane]
(R-HSA-5696928)
0.547
2
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB [nucleoplasm]
(R-HSA-3321990)
ACTB [cytosol]
(R-HSA-201861)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [plasma membrane]
(R-HSA-196016)
0.537
10
UniProt:Q05397 PTK2
11
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.536
2
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.527
2
UniProt:P36542 ATP5F1C
1
ATP5F1C [mitochondrial matrix]
(R-HSA-164577)
0.527
2
UniProt:O00483 NDUFA4
1
NDUFA4 [mitochondrial inner membrane]
(R-HSA-60617)
0.527
2
UniProt:O95573 ACSL3
2
ACSL3 [mitochondrial outer membrane]
(R-HSA-9632656)
ACSL3 [endoplasmic reticulum membrane]
(R-HSA-548787)
0.527
2
UniProt:Q8WUY1 THEM6
0.527
2
UniProt:Q9NVI7 ATD3A
0.527
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.527
2
UniProt:Q00325 S25A3
0.527
2
UniProt:Q9BVV7 TIMM21
2
TIMM21 [mitochondrial intermembrane space]
(R-HSA-9865416)
TIMM21 [mitochondrial inner membrane]
(R-HSA-1252042)
0.527
2
UniProt:Q92504 SLC39A7
1
SLC39A7 [endoplasmic reticulum membrane]
(R-HSA-442363)
0.527
2
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.527
3
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.527
2
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:O00750 PIK3C2B
1
PIK3C2B [cytosol]
(R-HSA-1604619)
0.525
2
UniProt:Q99952-1 PTPN18
0.524
5
IntAct:EBI-5590949 HAS
0.524
2
UniProt:Q15256 PTPRR
0.508
2
UniProt:P15309 ACP3
2
ACPP [azurophil granule membrane]
(R-HSA-6799214)
ACPP [plasma membrane]
(R-HSA-3229238)
0.472
2
UniProt:P49792 RANBP2
6
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(R-HSA-4551720)
monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope]
(R-HSA-4551599)
RANBP2 [nuclear envelope]
(R-HSA-2993756)
RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9718443)
RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702002)
RANBP2 [cytosol]
(R-HSA-157703)
0.463
3
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