Reactome | Vimentin [cytosol]

Vimentin [cytosol]

Stable Identifier

R-HSA-9646687

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Chaperone Mediated Autophagy (Homo sapiens)
  - GFAP binds LAMP2a multimer (Homo sapiens)
    - LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
      - Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - HSPA8 binds substrate (Homo sapiens)
    - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
      - Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)
    - HSPA8:Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
      - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - HSPA8:Substrate binds LAMP2a (Homo sapiens)
    - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - HSPA8:Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
      - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - Substrate:LAMP2a binds HSP90 (Homo sapiens)
    - Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
      - Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)
    - LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
      - Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
      - Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
- Late endosomal microautophagy (Homo sapiens)
  - HSPA8 binds substrate (Homo sapiens)
    - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
      - Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - HSPA8:substrate binds late endosomal phospholipids (Homo sapiens)
    - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
    - PL:HSPA8:Autophagy substrate [late endosome membrane] (Homo sapiens)
      - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
  - Substrate translocates into late endosomal lumen (Homo sapiens)
    - PL:HSPA8:Autophagy substrate [late endosome membrane] (Homo sapiens)
      - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)
- Macroautophagy (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Aggrephagy (Homo sapiens)
      - Aggresome dissociates from dynein and microtubule (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Homo sapiens)
        
        Poly-vimentin [cytosol] (Homo sapiens)
        
        Vimentin [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08670 VIM

Gene Names

VIM

Chain

initiator methionine:1, chain:2-466

Reference Genes

BioGPS Gene:7431 VIM

COSMIC (genes):VIM VIM

CTD Gene:7431 VIM

dbSNP Gene:7431 VIM

ENSEMBL:ENSG00000026025 VIM

ENSEMBL:ENSG00000026025.16 VIM

HGNC:12692 VIM

KEGG Gene (Homo sapiens):7431 VIM

Monarch:7431 VIM

NCBI Gene:7431 VIM

OMIM:193060 VIM

Reference Transcript

Other Identifiers

11731394_a_at

11755943_x_at

16702767

201426_PM_s_at

201426_s_at

3236965

3236966

3236967

3236968

3236970

3236971

3236972

3236973

3236974

3236975

3236976

3236977

3236978

3236980

3236987

3236988

3236991

3236993

3236995

3236997

3236999

3237000

3237001

3237002

3237003

3237004

34091_s_at

7431

75309_at

7926368

A_23_P161190

A_23_P161194

GE81272

GO:0002376

GO:0003723

GO:0003725

GO:0005198

GO:0005200

GO:0005212

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005777

GO:0005815

GO:0005829

GO:0005844

GO:0005856

GO:0005882

GO:0005886

GO:0005925

GO:0007010

GO:0010628

GO:0010977

GO:0014002

GO:0016020

GO:0016071

GO:0016363

GO:0019904

GO:0023052

GO:0030154

GO:0030424

GO:0031175

GO:0031252

GO:0031410

GO:0032967

GO:0042802

GO:0042995

GO:0043005

GO:0043226

GO:0043488

GO:0045103

GO:0045109

GO:0045111

GO:0045335

GO:0045727

GO:0048856

GO:0060020

GO:0060090

GO:0060395

GO:0070062

GO:0070307

GO:0071222

GO:0071225

GO:0071346

GO:0097110

GO:0098542

GO:1990254

GO:1990904

HMNXSV003038196

Hs.297753.0.A1_3p_a_at

ILMN_1782538

ILMN_2058251

PH_hs_0025444

TC10000126.hg

Z19554_s_at

Participates

as a repeated unit of

Poly-vimentin [cytosol] (Homo sapiens)

Other forms of this molecule

VIM(2-85) [cytosol]

VIM(86-466) [cytosol]

VIM(430-466) [cytosol]

VIM(2-429) [cytosol]

VIM(260-466) [cytosol]

VIM(2-259) [cytosol]

VIM [cytosol]

Vimentin [late endosome lumen]

Vimentin [microtubule organizing center]

Vimentin [lysosomal lumen]

Inferred To

VIM [cytosol] (Bos taurus)

VIM [cytosol] (Sus scrofa)

Vimentin [cytosol] (Gallus gallus)

vim [cytosol] (Xenopus tropicalis)

Vim [cytosol] (Mus musculus)

Vim [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_006717563.1, NP_003371.2

OpenTargets

ENSG00000026025

HPA

ENSG00000026025-VIM

GeneCards

P08670

Ensembl

ENSP00000224237, ENSG00000026025, ENST00000544301, ENSP00000446007, ENST00000224237

PRO

P08670

Pharos - Targets

P08670

Orphanet

19232

HMDB Protein

HMDBP01682

PDB

1GK7, 6YXK, 4YPC, 6BIR, 4MD5, 6ATI, 3TRT, 4MDJ, 3G1E, 3KLT, 3SWK, 3S4R, 4YV3, 1GK4, 3UF1, 4MD0, 5WHF, 1GK6, 4MDI, 3SSU, 4MCZ, 6ATF, 4MCY

Interactors (119)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.907	11
UniProt:P35900 KRT20	1	KRT20 [cytosol] (R-HSA-6809603)	0.83	8
UniProt:P07197 NFM			0.793	6
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.781	7
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.766	6
UniProt:O95251 KAT7	1	KAT7 [nucleoplasm] (R-HSA-3321823)	0.747	4
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.73	4
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.725	7
UniProt:Q8N3L3 TXLNB			0.718	6
UniProt:Q96PV4 PNMA5			0.718	6
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.706	29
UniProt:P48681 NEST			0.669	3
UniProt:Q6ZU52 K0408			0.666	4
UniProt:P41219 PERI			0.666	4
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.666	4
UniProt:P0DTD1-PRO_0000449633 REP			0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:P14340-PRO_0000037966			0.636	10
UniProt:Q14194 CRMP1	4	p-Y-CRMP1 [cytosol] (R-HSA-399784) CRMP1 [cytosol] (R-HSA-398120) p-T509,T514,S518,S522-CRMP1 [cytosol] (R-HSA-399777) p-S522-CRMP1 [cytosol] (R-HSA-399779)	0.635	3
UniProt:O76036 NCR1	1	NCR1 [plasma membrane] (R-HSA-197739)	0.611	3
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.602	6
UniProt:P83110-2 HTRA3			0.599	5
UniProt:Q9BYF1 ACE2	5	ACE2(18-805) [plasma membrane] (R-HSA-2022344) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [plasma membrane] (R-HSA-9683480)	0.599	4
UniProt:Q13835-2 PKP1			0.591	3
UniProt:P27958-PRO_0000037566			0.584	4
UniProt:P83110-1 HTRA3			0.577	4
UniProt:P05787 KRT8	1	KRT8 [cytosol] (R-HSA-446043)	0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:Q8TCE9 PPL13			0.556	3
IntAct:EBI-25881637 CCSB			0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:Q8IVT4 Q8IVT4			0.556	3
UniProt:Q9UJD0 RIMS3			0.556	3
IntAct:EBI-25881483 CCSB			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:Q6ZQX7-4 Q6ZQX74			0.556	3
UniProt:A0A024RCP2 A0A024RCP2			0.556	3
UniProt:Q8WUY3 PRUN2			0.556	3
UniProt:Q9Y3D0 CIAO2B	1	FAM96B [cytosol] (R-HSA-2161124)	0.556	3
UniProt:Q9H6U6 BCAS3			0.556	3
UniProt:Q7Z3I7 ZN572			0.556	3
UniProt:Q9H6L4 ARMC7			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.556	3
UniProt:Q6DHV7-2 Q6DHV72			0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q6NYC8 PPR18			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q9UBB4 ATX10			0.556	3
UniProt:B7ZLI8 B7ZLI8			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q9H7C4 SYNCI			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:Q4G1C9-2 Q4G1C92			0.556	3
UniProt:Q7Z403 TMC6	3	TMC6 [specific granule membrane] (R-HSA-6799712) TMC6 [plasma membrane] (R-HSA-6800446) TMC6 [tertiary granule membrane] (R-HSA-6800920)	0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:Q7Z614-3 SNX20			0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.556	3
IntAct:EBI-25861394 CCSB			0.556	3
UniProt:P17024 ZNF20	1	ZNF20 [nucleoplasm] (R-HSA-975024)	0.556	3
UniProt:Q9H270 VPS11	1	VPS11 [endosome membrane] (R-HSA-2197802)	0.556	3
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.556	3
UniProt:Q8N302-2 Q8N3022			0.556	3
UniProt:Q96LI6 HSFY1			0.556	3
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.556	3
UniProt:Q8WUE5 CT55			0.556	3
UniProt:Q96GL9 F163A			0.556	3
UniProt:P54819 AK2	1	AK2 [mitochondrial intermembrane space] (R-HSA-57822)	0.556	3
UniProt:O15287 FANCG	2	FANCG [cytosol] (R-HSA-420788) FANCG [nucleoplasm] (R-HSA-419532)	0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q5T1C6 THEM4	3	THEM4 [mitochondrial matrix] (R-HSA-162408) THEM4 [cytosol] (R-HSA-6809345) THEM4 [plasma membrane] (R-HSA-199437)	0.556	3
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.556	3
UniProt:Q92551 IP6K1	2	IP6K1 [nucleoplasm] (R-HSA-2023952) IP6K1 [cytosol] (R-HSA-1604591)	0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:Q14142 TRIM14	1	TRIM14 [cytosol] (R-HSA-5624345)	0.556	3
UniProt:P15923-3 TCF3			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.556	3
UniProt:Q13428-5 TCOF1			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q9BQE3 TUBA1C	9	AcK-TUBA1C [cytosol] (R-HSA-5618314) Ac K40 TUBA1C [axonemal microtubule] (R-HSA-5624856) TUBA1C folding intermediate [cytosol] (R-HSA-392798) TUBA1C unfolded [cytosol] (R-HSA-392772) L-isoglutamyl polyglycyl-TUBA1C [cytosol] (R-HSA-8867405) Polyglutamyl-TUBA1C [cytosol] (R-HSA-8867401) TUBA1C(1-448) [cytosol] (R-HSA-8955579) TUBA1C [axonemal microtubule] (R-HSA-5610439) TUBA1C [cytosol] (R-HSA-190590)	0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.556	3
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [nucleoplasm] (R-HSA-5625721) p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1 [nucleoplasm] (R-HSA-6803472) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523)	0.556	3
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.556	3
UniProt:P26651 ZFP36	2	p-S60,S186-ZFP36 [cytosol] (R-HSA-450496) ZFP36 [cytosol] (R-HSA-450562)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q9H9J2 MRPL44	1	MRPL44 [mitochondrial inner membrane] (R-HSA-5368245)	0.553	2
UniProt:P02766 TTR	2	TTR [extracellular region] (R-HSA-976883) TTR [azurophil granule lumen] (R-HSA-6799366)	0.553	2
UniProt:P61956 SUMO2	6	lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) SUMO2 [nucleoplasm] (R-HSA-2984281) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.553	2
UniProt:Q8N6T7 SIRT6	1	SIRT6 [nucleoplasm] (R-HSA-5685963)	0.553	2
UniProt:Q9NRH1 YAE1			0.553	2
UniProt:P15090 FABP4	3	FABP4 [cytosol] (R-HSA-2026069) FABP4 [lipid droplet] (R-HSA-163428) FABP4 [nucleoplasm] (R-HSA-2026072)	0.553	2
UniProt:Q925J2 Q925J2			0.527	2
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.527	3
UniProt:Q9H7C4-2 SYNC			0.527	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.524	4
UniProt:Q9NQH7 XPP3			0.508	2
UniProt:P63172 DYNLT1	3	DYNLT1 [secretory granule lumen] (R-HSA-6801497) DYNLT1 [extracellular region] (R-HSA-6806509) DYNLT1 [ficolin-1-rich granule lumen] (R-HSA-6801487)	0.508	2
UniProt:Q9C0D3 ZY11B			0.508	2
UniProt:P16278 GLB1	8	GLB1 W509C [lysosomal lumen] (R-HSA-2262732) GLB1 Y83C [lysosomal lumen] (R-HSA-2262735) GLB1 R482C [lysosomal lumen] (R-HSA-2262739) GLB1 W273L [lysosomal lumen] (R-HSA-2262738) GLB1 [lysosomal lumen] (R-HSA-1605623) GLB1 [ficolin-1-rich granule lumen] (R-HSA-6800968) GLB1 [extracellular region] (R-HSA-6806213) GLB1 [azurophil granule lumen] (R-HSA-6799124)	0.508	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.508	3
UniProt:P10619 CTSA	7	CTSA(29-480) [lysosomal lumen] (R-HSA-1181230) CTSA(29-326) [extracellular region] (R-HSA-6806187) CTSA(327-480) [extracellular region] (R-HSA-6806233) CTSA(29-326) [azurophil granule lumen] (R-HSA-6799135) CTSA(327-480) [azurophil granule lumen] (R-HSA-6799120) CTSA(29-326) [lysosomal lumen] (R-HSA-1605735) CTSA(327-480) [lysosomal lumen] (R-HSA-1605642)	0.508	2
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.508	2
UniProt:Q14457 BECN1	3	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.499	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.499	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:O95361 TRI16			0.463	3
UniProt:Q8UZC1 Q8UZC1			0.463	2

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