Reactome | GSDME (271-496) [cytosol]

GSDME (271-496) [cytosol]

Stable Identifier

R-HSA-9647615

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gasdermin-E (271-496), Gasdermin-E, C-terminal

Locations in the PathwayBrowser for interactor UniProt:Q96CG3 TIFA

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External Reference Information

External Reference

UniProt:O60443 GSDME

Gene Names

GSDME, DFNA5, ICERE1

Chain

chain:1-496, chain:1-270, chain:271-496

Reference Genes

BioGPS Gene:1687 GSDME

COSMIC (genes):GSDME GSDME

CTD Gene:1687 GSDME

dbSNP Gene:1687 GSDME

ENSEMBL:ENSG00000105928 GSDME

HGNC:2810 GSDME

KEGG:hsa:1687 GSDME

Monarch:1687 GSDME

NCBI Gene:1687 GSDME

OMIM:608798 GSDME

UCSC:O60443 GSDME

Reference Transcript

Other Identifiers

11719194_a_at

1687

17055910

203695_PM_s_at

203695_s_at

3041817

3041818

3041819

3041820

3041825

3041826

3041827

3041828

3041829

3041831

3041832

3041833

3041834

3041835

3041836

3041837

3041838

3041839

3041840

3041841

3041842

3041843

3041844

3041845

3041847

3041848

3041849

3041850

3041859

3041860

3041861

3041864

3041865

3041866

41872_at

8138602

A_23_P82449

A_33_P3221293

GE54686

GO:0002839

GO:0005215

GO:0005515

GO:0005546

GO:0005737

GO:0005829

GO:0005886

GO:0007605

GO:0008285

GO:0008289

GO:0012501

GO:0016020

GO:0022829

GO:0030154

GO:0042491

GO:0043410

GO:0050877

GO:0055085

GO:0070269

GO:0071356

GO:0098586

GO:0141201

GO:1901612

GO:2001244

HMNXSV003001929

HMNXSV003019197

ILMN_1670145

PH_hs_0023638

g4758153_3p_a_at

Participates

as an output of

Other forms of this molecule

GSDME(1-270) [cytosol]

GSDME [cytosol]

GSDME(1-270) E177V [cytosol]

GSDME(1-270) T196M [cytosol]

GSDME(1-270) G17D [cytosol]

GSDME(1-270) E134A [cytosol]

GSDME(1-270) N24D [cytosol]

GSDME E210* [cytosol]

GSDME(1-270) I217N [cytosol]

GSDME(1-270) W44C [cytosol]

GSDME(1-270) P212L [cytosol]

GSDME(1-270) D14Y [cytosol]

GSDME(1-270) D18V [cytosol]

GSDME W46* [cytosol]

GSDME(1-270) I137T [cytosol]

GSDME(1-270) R48I [cytosol]

GSDME(1-270) G199E [cytosol]

Inferred To

GSDME (271-496) [cytosol] (Gallus gallus)

GSDME [cytosol] (Bos taurus)

GSDME [cytosol] (Canis familiaris)

GSDME [cytosol] (Sus scrofa)

gsdmeb [cytosol] (Danio rerio)

gsdme [cytosol] (Xenopus tropicalis)

Gsdme [cytosol] (Mus musculus)

Gsdme [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001120925.1, XP_016867291.1, NP_004394.1, NP_001120926.1

OpenTargets

ENSG00000105928

ENSEMBL

ENSP00000339587, ENST00000342947, ENST00000419307, ENST00000645220, ENSP00000387119, ENST00000409970, ENSP00000494186, ENSP00000401332

HPA

ENSG00000105928-GSDME

PRO

O60443

Pharos - Targets

O60443

GlyGen

O60443

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.556	3
UniProt:Q86UL3 GPAT4	1	AGPAT6 [endoplasmic reticulum membrane] (R-HSA-549099)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	2
UniProt:O60939 SCN2B	1	SCN2B [plasma membrane] (R-HSA-197905)	0.527	2
UniProt:Q8N7X8 SIGL1			0.527	3
UniProt:O14975 SLC27A2	5	SLC27A2 [cytosol] (R-HSA-9033090) SLC27A2 [endoplasmic reticulum membrane] (R-HSA-193386) SLC27A2 [plasma membrane] (R-HSA-6806316) SLC27A2 [specific granule membrane] (R-HSA-6799565) SLC27A2 [peroxisomal membrane] (R-HSA-389579)	0.527	2
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	2
UniProt:Q969V5 MUL1	2	PolyUb-MUL1 [mitochondrial outer membrane] (R-HSA-6783184) MUL1 [mitochondrial outer membrane] (R-HSA-2993772)	0.527	2

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