Reactome | S-Farn-Me KRAS4B [plasma membrane]

S-Farn-Me KRAS4B [plasma membrane]

Stable Identifier

R-HSA-9647815

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p21A (K-Ras 2A), Transforming protein p21A, K-Ras 2A, Ki-Ras, c-K-ras

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
        
        NMDA-activated RASGRF1 activates RAS (Homo sapiens)
        
        p21 RAS:GDP [plasma membrane] (Homo sapiens)
        
        mature p21 RAS [plasma membrane] (Homo sapiens)
        
        S-Farn-Me KRAS4B [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP [plasma membrane] (Homo sapiens)
        
        mature p21 RAS [plasma membrane] (Homo sapiens)
        
        S-Farn-Me KRAS4B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01116-2 KRAS

Gene Names

KRAS, KRAS2, RASK2

Other Identifiers

11717962_x_at

11717963_a_at

11717964_a_at

11717965_s_at

16762399

1940_at

204009_PM_s_at

204009_s_at

204010_PM_s_at

204010_s_at

214352_PM_s_at

214352_s_at

231640_PM_at

231640_at

32159_at

3447860

3447862

3447864

3447865

3447866

3447867

3447868

3447869

3447870

3447871

3447872

3447873

3447874

3447879

3447880

3447884

3447885

3447886

3845

3958621

7961865

A_23_P306500

A_23_P306507

A_23_P45140

A_33_P3317815

GE61031

GO:0000139

GO:0000165

GO:0000166

GO:0001934

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005737

GO:0005739

GO:0005741

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0005886

GO:0005925

GO:0007010

GO:0007165

GO:0007265

GO:0008283

GO:0008542

GO:0009898

GO:0010467

GO:0010628

GO:0012501

GO:0012505

GO:0014009

GO:0016020

GO:0016601

GO:0016787

GO:0019003

GO:0021897

GO:0023052

GO:0030036

GO:0030154

GO:0030857

GO:0032228

GO:0035022

GO:0035914

GO:0036211

GO:0042802

GO:0043226

GO:0043495

GO:0043524

GO:0044877

GO:0048169

GO:0048856

GO:0048873

GO:0050877

GO:0051146

GO:0051402

GO:0060090

GO:0060252

GO:0060441

GO:0060509

GO:0098772

HMNXSV003005517

HMNXSV003016084

Hs.184050.0.S1_3p_a_at

Hs.184050.1.A1_3p_a_at

Hs.184050.4.A1_3p_at

ILMN_1652104

ILMN_1728071

M54968_at

PH_hs_0028364

PH_hs_0030345

TC12001314.hg

g4826811_3p_a_at

Participates

as an output of

as a component of

S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)

as an input of

as a member of

mature p21 RAS [plasma membrane] (Homo sapiens)

Other forms of this molecule

S-Farn-Me KRAS4B [cytosol]

pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]

pS181-S-Farn-Me KRAS4B [plasma membrane]

S-Farn-Me KRAS4B [endoplasmic reticulum membrane]

S-Farn KRAS4B [endoplasmic reticulum membrane]

S-Farn proKRAS4B [endoplasmic reticulum membrane]

pro-KRAS4B [cytosol]

Inferred To

KRAS [plasma membrane] (Bos taurus)

KRAS [plasma membrane] (Canis familiaris)

KRAS [plasma membrane] (Gallus gallus)

KRAS [plasma membrane] (Sus scrofa)

S-Farn-Me KRAS4B [plasma membrane] (Caenorhabditis elegans)

S-Farn-Me KRAS4B [plasma membrane] (Drosophila melanogaster)

S-Farn-Me KRAS4B [plasma membrane] (Mus musculus)

S-Farn-Me KRAS4B [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

S-farnesyl-L-cysteine methyl ester at 185

Coordinate

185

PsiMod Name

S-farnesyl-L-cysteine methyl ester

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester.

Cross References

RefSeq

NP_004976.2, NP_203524.1, XP_011518955.1, XP_006719132.1

Guide to Pharmacology - Targets

2824

OpenTargets

ENSG00000133703

ZINC - Substances

RASK_HUMAN

ZINC target

P01116

PRO

P01116

PDB

8B00, 7A1W, 7EW9, 4NMM, 8T72, 4Q02, 7KYZ, 4M21, 4TQA, 7RT2, 1KZO, 5V9O, 6FA1, 6GJ5, 5VPI, 6UT0, 6PGP, 7RSE, 6ASA, 7EYX, 8AQ5, 4M1S, 7RSC, 6N2K, 8G47, 7NY8, 5O2S, 7A47, 6GQX, 6MBT, 7U8H, 5VQ8, 8FMI, 8I5E, 1N4Q, 7OO7, 4EPR, 6ZL5, 8I5C, 7R0Q, 8EBZ, 7RT3, 6N2J, 8T4V, 6O53, 8FMJ, 7YUZ, 6B0V, 6V5L, 4OBE, 6WS2, 6MBU, 3GFT, 8G4F, 4LDJ, 8TBJ, 8G42, 7MQU, 7YCE, 6PTW, 8QUG, 6WS4, 7T47, 6XGV, 8T73, 8AZZ, 7RT5, 5OCO, 2MSC, 8T71, 1N4S, 6VJJ, 8F0M, 8TBN, 6P0Z, 8B69, 7OK4, 7LGI, 7RT4, 8EPW, 8UN5, 5WHB, 7RT1, 7ROV, 2MSD, 6ARK, 4WA7, 8QW6, 8G9Q, 6MQN, 8AFB, 6GJ7, 5OCT, 6EPP, 6T5B, 5OCG, 7ACF, 7F0W, 4EPX, 6GOG, 8ONV, 1D8D, 8TXH, 4LUC, 6W4E, 6GOE, 7EWB, 6O4Y, 7W5R, 5WPM, 7RP4, 6GQY, 4L8G, 8JGD, 4QL3, 7LZ5, 6BOF, 8TXG, 5YY1, 6USZ, 6ZLI, 6P8W, 7ACH, 8AZY, 8EDY, 6O4Z, 4EPW, 5V9L, 7TLE, 7OK3, 4EPT, 4M1T, 7C41, 7RPZ, 8AFD, 8STM, 6CU6, 8TXE, 5VP7, 6MS9, 7TLK, 5MLA, 5YXZ, 6QUU, 6JTN, 8T74, 6OB3, 8ECR, 7ACQ, 7RP2, 8QVU, 4LYH, 8EZG, 6T5V, 6E6F, 5V9U, 6EPN, 6CC9, 4PZZ, 5VQ2, 7KFZ, 6F76, 2MSE, 8DNK, 8AZX, 5WHA, 7Q9U, 8CX5, 4PZY, 5MLB, 7VVB, 8JJS, 4DSO, 7MDP, 6B0Y, 5VQ1, 6PQ3, 6O36, 5UK9, 8I5D, 5V6S, 8G9P, 6TAN, 8TBK, 7SCX, 4Q03, 6MTA, 5TAR, 8EER, 6P8X, 8DGS, 6PTS, 6VC8, 6H46, 7TLG, 5TB5, 5VQ0, 5UFQ, 6JTO, 4M1W, 4LPK, 6JTP, 6T5U, 5VBM, 6GJ8, 5VQ6, 6EPM, 7STF, 7RP3, 6P8Y, 8UN3, 8X6R, 7A1X, 8DGT, 6V65, 6QUV, 4LV6, 8DNJ, 7KMR, 6GOM, 7O70, 6BP1, 8G4H, 4DSN, 5WHE, 6QUW, 4M1O, 8T75, 7EWA, 6GQT, 6FA2, 8QU8, 8TBF, 8DVG, 4LRW, 5V71, 4M22, 6TAM, 6H47, 7R0M, 6WGN, 8AQ7, 5O2T, 5VPZ, 5KYK, 8TBL, 6ASE, 6EPO, 6FA3, 6GQW, 6O51, 8AFC, 6YR8, 4LYJ, 6FA4, 6XHA, 4Q01, 1D8E, 7C40, 6MBQ, 6QUX, 6MNX, 7R0N, 8EIE, 4EPV, 6USX, 4M1Y, 5XCO, 6P8Z, 5VPY, 8DNI, 9AX6, 6W4F, 8JHL, 6OB2, 6OIM, 5F2E, 1KZP, 5USJ, 8B6I, 6GOD, 4TQ9, 8QW7, 7A1Y, 8TBH, 6GOF, 5WLB, 7SCW, 6V6F, 6YXW, 5WHD, 1N4P, 5V6V, 6M9W, 7LC1, 8FMK, 8TBM, 5UFE, 1N4R, 6O46, 6PGO, 5UQW, 8UN4, 7YCC, 6CCX, 6GJ6, 8B78, 5W22, 6E6G, 4EPY, 6MQG, 7ACA, 8AZV, 5US4, 7LC2, 6XHB, 8STN, 7T1F, 7YV1, 4LYF, 6CCH, 6XGU, 6EPL, 8AZR

IntEnz

3.6.5.2

GeneCards

P01116

HPA

ENSG00000133703-KRAS

Ensembl

ENSP00000308495, ENSG00000133703, ENST00000688940, ENST00000311936, ENSP00000509238, ENSP00000508921, ENST00000685328, ENSP00000256078, ENST00000256078

Pharos - Targets

P01116

Orphanet

16312

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.695	6
UniProt:Q99755 PIP5K1A	1	PIP5K1A [cytosol] (R-HSA-1806260)	0.661	9
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.615	4
UniProt:Q96II5 Q96II5			0.556	3
UniProt:P50749 RASF2			0.544	2
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.519	2
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.519	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.483	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.483	2
UniProt:P28288 ABCD3	2	ABCD3 [cytosol] (R-HSA-1456459) ABCD3 [peroxisomal membrane] (R-HSA-1456468)	0.483	2
UniProt:P01111 NRAS	20	NRAS [tertiary granule membrane] (R-HSA-6800190) NRAS Q61H [plasma membrane] (R-HSA-9649678) NRAS G13R [plasma membrane] (R-HSA-9649672) NRAS G13V [plasma membrane] (R-HSA-9649675) NRAS G13C [plasma membrane] (R-HSA-9649669) NRAS G12V [plasma membrane] (R-HSA-9649666) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS [plasma membrane] (R-HSA-62725) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906)	0.483	2
UniProt:Q7KZI7 MARK2			0.483	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2

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