Reactome | S-Farn-Me PalmS NRAS [plasma membrane]

S-Farn-Me PalmS NRAS [plasma membrane]

Stable Identifier

R-HSA-9647910

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p21/N-Ras, Transforming protein N-Ras

Icon

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
        
        NMDA-activated RASGRF1 activates RAS (Homo sapiens)
        
        p21 RAS:GDP [plasma membrane] (Homo sapiens)
        
        mature p21 RAS [plasma membrane] (Homo sapiens)
        
        S-Farn-Me PalmS NRAS [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP [plasma membrane] (Homo sapiens)
        
        mature p21 RAS [plasma membrane] (Homo sapiens)
        
        S-Farn-Me PalmS NRAS [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01111 NRAS

Gene Names

NRAS, HRAS1

Chain

chain:1-186, propeptide:187-189

Reference Genes

BioGPS Gene:4893 NRAS

COSMIC (genes):NRAS NRAS

CTD Gene:4893 NRAS

dbSNP Gene:4893 NRAS

ENSEMBL:ENSG00000213281 NRAS

HGNC:7989 NRAS

KEGG:hsa:4893 NRAS

Monarch:4893 NRAS

NCBI Gene:4893 NRAS

OMIM:164790 NRAS

UCSC:P01111 NRAS

Reference Transcript

RefSeq:NM_002524.4 NRAS

Other Identifiers

11719188_at

11719189_at

1539_at

16691262

202647_PM_s_at

202647_s_at

224985_PM_at

224985_at

2429260

2429262

2429263

2429264

2429265

2429266

2429267

2429268

2429270

2429271

2429273

2429274

4893

7918813

A_23_P63190

A_33_P3317825

GE79523

GO:0000139

GO:0000165

GO:0001938

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005789

GO:0005794

GO:0005829

GO:0005886

GO:0007165

GO:0007265

GO:0016020

GO:0016787

GO:0019003

GO:0030154

GO:0043226

GO:0044877

GO:0045445

GO:0070062

GO:0070821

GO:0098772

HMNXSV003016401

Hs.260523.1.A1_3p_at

ILMN_1775759

PH_hs_0013620

TC01003014.hg

X02751_at

g6006027_3p_a_at

Participates

as a member of

Other forms of this molecule

proNRAS [cytosol]

S-Farn-proNRAS [endoplasmic reticulum membrane]

S-Farn NRAS [endoplasmic reticulum membrane]

S-Farn-Me NRAS [endoplasmic reticulum membrane]

S-Farn-Me PalmS NRAS [Golgi membrane]

S-Farn-Me NRAS [plasma membrane]

NRAS [plasma membrane]

NRAS Q60E [plasma membrane]

NRAS G12D [plasma membrane]

NRAS G12S [plasma membrane]

NRAS G13D [plasma membrane]

NRAS Q61K [plasma membrane]

NRAS Q61L [plasma membrane]

NRAS Q61R [plasma membrane]

NRAS Q61P [plasma membrane]

NRAS G12A [plasma membrane]

NRAS G12R [plasma membrane]

NRAS G12C [plasma membrane]

NRAS G12V [plasma membrane]

NRAS G13C [plasma membrane]

NRAS G13V [plasma membrane]

NRAS G13R [plasma membrane]

NRAS Q61H [plasma membrane]

NRAS [tertiary granule membrane]

Inferred To

NRAS [plasma membrane] (Bos taurus)

NRAS [plasma membrane] (Canis familiaris)

S-Farn-Me PalmS NRAS [plasma membrane] (Caenorhabditis elegans)

S-Farn-Me PalmS NRAS [plasma membrane] (Danio rerio)

S-Farn-Me PalmS NRAS [plasma membrane] (Drosophila melanogaster)

S-Farn-Me PalmS NRAS [plasma membrane] (Gallus gallus)

S-Farn-Me PalmS NRAS [plasma membrane] (Mus musculus)

S-Farn-Me PalmS NRAS [plasma membrane] (Rattus norvegicus)

S-Farn-Me PalmS NRAS [plasma membrane] (Sus scrofa)

Modified Residues

Name

S-farnesyl-L-cysteine methyl ester at 186

Coordinate

186

PsiMod Name

S-farnesyl-L-cysteine methyl ester

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester.

Name

S-palmitoyl-L-cysteine at 181

Coordinate

181

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Cross References

RefSeq

NP_002515.1

Guide to Pharmacology - Targets

2823

OpenTargets

ENSG00000213281

ENSEMBL

ENSP00000358548, ENST00000369535

ZINC - Substances

RASN_HUMAN

ZINC target

P01111

PRO

P01111

GlyGen

P01111

PDB

6ULR, 6ZIR, 7OW5, 6ZIZ, 6MPP, 7OW4, 3CON, 6ULK, 6ULI, 7OW3, 7OW6, 5UHV, 6ULN, 2N9C, 6E6H, 6WGH, 8VM2, 8TBI, 7F68, 6ZIO, 7PB2, 6UON

HPA

ENSG00000213281-NRAS

Pharos - Targets

P01111

Orphanet

NRAS

ZINC - Predictions - Purchasable

RASN_HUMAN

HMDB Protein

HMDBP08527

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.925	12
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.806	6
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.527	2
UniProt:P28028	6	phospho-hyperphosphorylated BRAF [plasma membrane] (R-MMU-5675199) phospho-p-S365,S446,S729 BRAF [cytosol] (R-MMU-5672667) BRAF [cytosol] (R-MMU-167224) phospho-p-S446,T599,S602,S729 BRAF [plasma membrane] (R-MMU-5672679) phospho-p-S446,S729-BRAF [cytosol] (R-MMU-5672673) phospho-p-S446,T599,S602,S729 BRAF [cytosol] (R-MMU-5672676)	0.499	2
UniProt:Q99N57	11	phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-MMU-5672664) phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-MMU-5672665) phospho-p-S621-RAF1 [cytosol] (R-MMU-206028) phospho-p-Y-RAF1 [cytosol] (R-MMU-9732747) RAF1 [cytosol] (R-MMU-167205) phospho-p-S259,S621-RAF1 [cytosol] (R-MMU-109786) phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-MMU-5675420) phospho-p-S621-RAF1 [plasma membrane] (R-MMU-206222) phospho-hyperphosphorylated RAF1 [plasma membrane] (R-MMU-5675193) phospho-p-S338-RAF1 [cytosol] (R-MMU-5624469) phospho-p-S338,Y340,Y341-RAF1 [cytosol] (R-MMU-5624465)	0.499	2
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.483	2
UniProt:Q658P3 STEAP3	2	STEAP3 [plasma membrane] (R-HSA-9714848) STEAP3 [endosome membrane] (R-HSA-917861)	0.483	2

Cite Us!