Reactome | RAS proteins are depalmitoylated

RAS proteins are depalmitoylated

Stable Identifier

R-HSA-9647994

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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RAS proteins undergo a dynamic palmitoylation and depalmitoylation cycle that regulates their association with membranes and thus their localization and function (Hancock et al, 1989; Swarthout et al, 2005; reviewed in Gysin et al, 2011; Lin et al, 2017; Ahearn et al, 2018). Depalmitoylation is catalyzed by the acyl-protein thioesterase LYPLA1, also known as APT1, or by members of the ABHD17 family (Dekker et al, 2010; Lin and Conibear, 2015; reviewed in Lin et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
20418879	Small-molecule inhibition of APT1 affects Ras localization and signaling Waldmann, H, Bastiaens, PI, Rusch, M, Vartak, N, Brunsveld, L, Rocks, O, Coates, GW, Menninger, S, Kramer, JW, Gerauer, M, Balamurugan, R, Renner, S, Rauh, D, Schölermann, B, Dekker, FJ, Wetzel, S, Hedberg, C	Nat. Chem. Biol.	2010
21779505	Therapeutic strategies for targeting ras proteins McCormick, F, Salt, M, Young, A, Gysin, S	Genes Cancer	2011
2661017	All ras proteins are polyisoprenylated but only some are palmitoylated Hancock, JF, Childs, JE, Magee, AI, Marshall, CJ	Cell	1989
29311131	Posttranslational Modifications of RAS Proteins Philips, MR, Zhou, M, Ahearn, I	Cold Spring Harb Perspect Med	2018
28630138	Targeting the Ras palmitoylation/depalmitoylation cycle in cancer Conibear, E, Davis, NG, Lin, DTS	Biochem. Soc. Trans.	2017
16000296	DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras Linder, ME, Deschenes, RJ, Croke, MR, Swarthout, JT, Lobo, S, Farh, L, Greentree, WK	J. Biol. Chem.	2005
26701913	ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization Conibear, E, Lin, DT	Elife	2015